Oxidative stress impairs processive motility of the axonal transport motor KIF1A.

Adrien P Chen, Himanshu Pandey, William O Hancock

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adrien P ChenDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.

Himanshu PandeyDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.

William O HancockDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA; Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA. Electronic address: woh1@psu.edu.

Funding

Molecular mechanism of bidirectional transportR35GM139568 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI William Olaf Hancock · 2021 to 2026

$4.9M

NIGMS NIH HHS R35 GM139568

6 · The paper itself

Abstract

The kinesin-3 family member, KIF1A is an essential motor protein that carries out intracellular transport in neurons. Previous work has established that: (1) intracellular transport can be impaired in neurodegenerative diseases such as Alzheimer's and Parkinson's; and (2) oxidative stress is elevated in neurodegenerative diseases and during aging. To date there has not been a systematic study of the effects of reactive oxygen species on kinesin motor proteins. We hypothesized that oxidative stress can damage kinesin, leading to decreased motility. To test our hypothesis, we treated KIF1A in vitro with varying concentrations of hydrogen peroxide (H

Indexed as

Axonal TransportKinesinsOxidative StressAnimalsHydrogen PeroxideHydrogen PeroxideKinesinsfree radicalskinesinmicrotubuleneurodegenerative diseaseoxidative stress

Identifiers

PMID42001941

DOI10.1016/j.jbc.2026.111471

PMCPMC13196361

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.