Evidence map›Paper›PMID 42001939›Full record

ArticleThe Journal of biological chemistry2026

Deletion of mitochondrial calcium uniporter enhances calcium signals by slowing calcium clearance and triggers adaptive transcriptomic remodeling.

Rajesh Bhardwaj, Abdull J Massri, Gary S Bird, Anant B Parekh

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajesh BhardwajMolecular & Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.
Abdull J MassriIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.
Gary S BirdMolecular & Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.
Anant B ParekhMolecular & Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA. Electronic address: anant.parekh@nih.gov.

Funding

Calcium Signaling in Health and DiseaseZIAES103353 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PAREKH, ANANT · 2020 to 2025
$15.5M
Intramural NIH HHS ZIA ES103353
6 · The paper itself

Abstract

Mitochondrial Ca

Indexed as

CalciumCalcium ChannelsCalcium SignalingGene DeletionMitochondriaTranscriptomeAnimalsCytosolHumansCalciumCalcium Channelsmitochondrial calcium uniporterCa(2+) release-activated Ca(2+) (CRAC) channelcalcium homeostasiscytosolic calcium clearancemitochondrial calcium uniporter (MCU)plasma membrane Ca(2+) ATPase (PMCA)store-operated calcium entry (SOCE)transcriptomics

Identifiers

PMID42001939
PMCPMC13197774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.