Evidence map›Paper›PMID 42001691›Full record

ArticleUltrasonics sonochemistry2026

Green and efficient ultrasound-assisted supramolecular solvent extraction of Plantago asiatica L.: Process optimization, mechanism, and hypouricemic efficacy.

Wenwen Ding, Xiao Han, Zhijia Lu, Haixin Peng, Jingjing Lv, Huiwen Wang, Kang An, Jun Ma, Qianwei Qu, Yanyan Liu and 1 more

Abstract read
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In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenwen DingHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Xiao HanHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Chengdu Agricultural College, Chengdu 611130, China.
Zhijia LuHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Haixin PengHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Jingjing LvHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Huiwen WangHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Kang AnHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Jun MaHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Qianwei QuHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address: qwqu@neau.edu.cn.
Yanyan LiuHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address: Liuyanyan@neau.edu.cn.
Yanhua LiHeilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address: liyanhua@neau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plantago asiatica L. (PA), a traditional Chinese medicinal and edible plant, is rich in the hypouricemic bioactive components plantamajoside (PMS) and acteoside (ACT). This study pioneers the development of an efficient and environmentally friendly ultrasonic-assisted supramolecular solvent extraction (SUPRAS-UAE) method for the extraction of PMS and ACT. Additionally, it elucidates the sonochemical mechanisms underlying SUPRAS-UAE and conducts a comparative analysis of its extraction efficiency against conventional methods. The ultrasonic apparatus utilized was an SB25-12DTD power-adjustable heated cleaner operating at 40 kHz. The SUPRAS solvent system comprised 9% (v/v) decanoic acid, 38% (v/v) ethanol, and 53% (v/v) water, with a pH of 6. Through optimization using single-factor experiments and response surface methodology, the optimal extraction conditions were determined to be an ultrasonic power of 840 W, an ultrasonic duration of 50 min, an ultrasonic temperature of 53℃, and a liquid-solid ratio of 82 mL/g. Mechanistically, the application of ultrasound facilitated the dynamic reorganization of SUPRAS micelles and the mechanical disruption of PA cell walls, thereby synergistically enhancing the release of the target components. Compared to conventional extraction methods, SUPRAS-UAE demonstrated superior extraction efficiency, environmental sustainability, and solvent recyclability.

Indexed as

Chemical FractionationGreen Chemistry TechnologyPlantagoSolventsUltrasonic WavesCatecholsGlucosidesPhenolsTemperatureCatecholsGlucosidesPhenolsplantamajosideSolventsActeosidePlantago asiatica L.PlantamajosideSupramolecular solventUltrasound-assisted extraction

Identifiers

PMID42001691
PMCPMC13103589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.