Evidence map›Paper›PMID 42001671›Full record

Trial reportSleep medicine2026

Actigraphy-based differences in sleep in those receiving opioid versus non-opioid therapy postsurgical removal of impacted third molars: a pilot study from the opioid analgesic reduction study (OARS).

R Nisha Aurora, Pamela B Matheson, Shou-En Lu, Tracy Andrews, Patricia Greenberg, Janine Fredericks-Younger, Hans Malmstrom, Michael Miloro, Gary Warburton, Brent B Ward and 2 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

R Nisha AuroraDivision of Pulmonary, Critical Care, and Sleep Medicine, NYU Grossman School of Medicine, NY, NY, USA. Electronic address: rashmi.aurora@nyulangone.org.
Pamela B MathesonSchool of Dental Medicine, Rutgers University, Newark, NJ, USA; Amherst College, Amherst, MA, USA.
Shou-En LuSchool of Public Health, Rutgers University, Piscataway, NJ, USA.
Tracy AndrewsSchool of Public Health, Rutgers University, Piscataway, NJ, USA.
Patricia GreenbergSchool of Public Health, Rutgers University, Piscataway, NJ, USA.
Janine Fredericks-YoungerSchool of Dental Medicine, Rutgers University, Newark, NJ, USA.
Hans MalmstromEastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Michael MiloroCollege of Dentistry, University of Illinois - Chicago, Chicago, Ill, USA.
Gary WarburtonSchool of Dentistry, University of Maryland, Baltimore, MD, USA.
Brent B WardSchool of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Vincent B ZiccardiSchool of Dental Medicine, Rutgers University, Newark, NJ, USA.
Cecile A FeldmanSchool of Dental Medicine, Rutgers University, Newark, NJ, USA.

Funding

Opiod Analgesic Reduction Study (OARS): Managing Acute Post-Operative Surgical PainUG3DE028860 · NIDCR · RBHS-SCHOOL OF DENTAL MEDICINE · PI FELDMAN, CECILE · 2019 to 2019
$629k
NIDCR NIH HHS UG3 DE028860
6 · The paper itself

Abstract

STUDY

objectivesOpioid medications are routinely used for short-term pain management after surgery. However, data on the effects of postsurgical opioid use on sleep is limited. The goal of this pilot study was to examine differences in objective sleep metrics between those on opioid versus non-opioid therapy for pain management in the immediate postsurgical period using participants in the pilot study from the Opioid Analgesic Reduction Study (OARS) and to determine if sex modifies the association.

methodsThe OARS study is a randomized, multisite study designed for people undergoing surgical removal of impacted third molars. Adult participants were stratified by sex and randomized to a treatment group. Participants wore an actigraph monitor for three days post-surgery. Actigraph-derived outcomes included total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE). Subjective survey data, including the Brief Pain Inventory (BPI) and Pain and Sleep Questionnaire (PSQ-3), were collected.

resultsData from 41 of the 50 pilot study participants who had full actigraphy data was included. The opioid group (n = 19) experienced more WASO on nights 1 and 3 than the nonopioid group (n = 22). The difference between the nonopioid and opioid groups was -22.3 min [90%CI:-42.8,-1.9] and -21.5 min [90%CI -41.9,-1.0], respectively. The noted difference was driven by men in the opioid group. In contrast, differences between treatment groups with regards to subjective surveys was driven by women. Women in the opioid group had worse mean PSQ-3 scores (p = 0.09): mean difference = -1.3 [90%CI:-2.4,-0.2] and -1.3 [90%CI:-2.3,-0.3] after nights 1 and 2, respectively.

conclusionPostsurgical opioid therapy is associated with worse objective and subjective sleep compared to non-opioid therapy. The associations are modified by sex.

Indexed as

Analgesics, Non-NarcoticAnalgesics, OpioidMolar, ThirdPostoperative PainSleepTooth, ImpactedActigraphyAdultFemaleHumansMalePain ManagementPain MeasurementPilot ProjectsSurveys and QuestionnairesTooth ExtractionAnalgesics, Non-NarcoticAnalgesics, OpioidActigraphyOpioidsSleep quantity

Identifiers

PMID42001671
PMCPMC13299139

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.