ArticleMedicina oral, patologia oral y cirugia bucal2026
Effect of intraoperative platelet-rich plasma on inferior alveolar nerve neurosensory outcomes after high-risk mandibular third molar extraction.
Article in Medicina oral, patologia oral y cirugia bucal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInferior alveolar nerve (IAN) injury is a relevant complication of mandibular third molar extraction, particularly in radiologically high-risk cases. Platelet-rich plasma (PRP) is a safe and accessible autologous product, but its preventive effect on IAN neurosensory impairment remains unknown. MATERIALS AND
methodsAn ambispective cohort study included 300 high-risk mandibular third molar extractions. Patients received intraoperative PRP (n=144) or no PRP (n=156). The primary outcome was IAN neurosensory impairment at 1 week. Secondary outcomes were time to recovery and persistence at 6 months. Multivariable and propensity score-weighted analyses were performed.
resultsIAN impairment at 1 week occurred in 18.0% of cases and was less frequent in the PRP group (11.1% vs 24.4%), with an absolute risk reduction of 13.2% (number needed to treat=8). PRP use remained independently associated with lower early IAN impairment. Group differences were evident after 2 months. PRP was not associated with shorter recovery time or reduced long-term persistence. Increasing age was associated with worse neurosensory outcomes.
conclusionsIn a radiologically high-risk population undergoing mandibular third molar extraction, intraoperative platelet-rich plasma use was associated with a reduction in early inferior alveolar nerve neurosensory impairment, without a measurable effect on long-term recovery or persistence. These findings suggest that PRP may act as a preventive intervention during the acute postoperative phase rather than as a treatment for established nerve injury.
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