Evidence map›Paper›PMID 42001483›Full record

ReviewCancer discovery2026

A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception.

Monte M Winslow, Mohamed A Ahmed, Christine D Berg, James R M Black, Julian Downward, Ramaswamy Govindan, Roy S Herbst, John V Heymach, Elizabeth M Jaffee, Norbert Kraut and 12 more

Abstract readReview
In one paragraph

Review in Cancer discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Monte M WinslowDepartment of Genetics, Stanford University School of Medicine, Stanford, California.ORCID 0000-0002-5730-9573
Mohamed A AhmedAmerican Association for Cancer Research , Philadelphia, Pennsylvania.ORCID 0000-0003-4476-0768
Christine D BergEarly Cancer Detection Consultant, NCI (retired), Bethesda, Maryland.ORCID 0000-0002-7649-2844
James R M BlackCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-5598-7752
Julian DownwardOncogene Biology Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-2331-4729
Ramaswamy GovindanDivision of Oncology, Washington University, St. Louis, Missouri.ORCID 0000-0002-6964-9612
Roy S HerbstYale Cancer Center, Yale University School of Medicine, Smilow Cancer Hospital, New Haven, Connecticut.ORCID 0000-0003-2535-5847
John V HeymachDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-9068-8942
Elizabeth M JaffeeSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-3841-6549
Norbert KrautDiscovery Research, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.ORCID 0000-0003-3941-7105
Miriam MeradDepartment of Immunology and Immunotherapy, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID 0000-0002-4481-7827
Matthew MeyersonDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-9133-8108
Tej PandyaCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-1816-1211
Katerina PolitiDepartments of Pathology and Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0001-6064-4527
Arati V RaoThoracic Oncology Development Head, Pfizer (United States), New York, New York.ORCID 0009-0004-2922-710X
Charles M RudinDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-5204-3465
Jean-Charles SoriaR&D, Amgen (United States), Thousand Oaks, California.ORCID 0000-0001-9597-0701
Yuning J TangDepartment of Genetics, Stanford University School of Medicine, Stanford, California.ORCID 0009-0006-7037-2901
Kwok-Kin WongLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.ORCID 0000-0001-6323-235X
Timothy A YapTherapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-2154-3309
Charles SwantonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, United Kingdom.ORCID 0000-0002-4299-3018
AACR Lung Cancer Task Force

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Advances in targeted therapies, immunotherapy, and early detection have revolutionized lung cancer treatment and extended survival. Nonetheless, lung cancer remains highly fatal. Here, we identify knowledge gaps and propose critical areas of future research, aligning with the mission of the American Association for Cancer Research (AACR) Lung Cancer Task Force. We delineate research priorities, including advancing prevention initiatives, enhancing early detection strategies, developing novel treatments, and refining patient stratification. Addressing disparities and increasing efforts on relatively neglected lung cancer subtypes are also essential. Finally, international collaboration, centralized clinical trial databases, novel clinical trial designs, and artificial intelligence-driven analytics should accelerate precision medicine and aid in elucidating drug resistance mechanisms. Together, these efforts promise to improve patient outcomes. SIGNIFICANCE: Despite substantial progress in understanding disease biology and improving therapy, lung cancer remains the leading cause of global cancer-related deaths. The members of the AACR Lung Cancer Task Force describe areas of unmet need and define near-term research priorities and opportunities to reduce lung cancer morbidity and mortality.

Indexed as

Lung NeoplasmsEarly Detection of CancerHumansPrecision Medicine

Identifiers

PMID42001483
PMCPMC7619086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.