Evidence map›Paper›PMID 42001422›Full record

ArticleSTAR protocols2026

Protocol for developing a surgically operated model to mimic human glioblastoma resection and recurrence.

Perrine Schneller, Julien Pierson, Joël Daouk, Fabien Rech, Matthieu Doyen, Sophie Pinel, Muriel Barberi-Heyob

Abstract read
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Perrine SchnellerCRAN, UMR 7039, Université de Lorraine, CNRS, 54505 Vandœuvre-lès-Nancy, France. Electronic address: perrine.schneller@univ-lorraine.fr.
Julien PiersonCRAN, UMR 7039, Université de Lorraine, CNRS, 54505 Vandœuvre-lès-Nancy, France. Electronic address: julien.pierson@univ-lorraine.fr.
Joël DaoukCRAN, UMR 7039, Université de Lorraine, CNRS, 54505 Vandœuvre-lès-Nancy, France.
Fabien RechCRAN, UMR 7039, Université de Lorraine, CNRS, 54505 Vandœuvre-lès-Nancy, France; Faculté de Médecine de Nancy, Université de Lorraine, 9 avenue de la Forêt de Haye, 54505 Vandœuvre-lès-Nancy, France; Department of Neurosurgery, CHRU-Nancy, 54000 Nancy, France.
Matthieu DoyenUniversité de Lorraine, IADI, INSERM U1254, 54000 Nancy, France.
Sophie PinelCRAN, UMR 7039, Université de Lorraine, CNRS, 54505 Vandœuvre-lès-Nancy, France.
Muriel Barberi-HeyobCRAN, UMR 7039, Université de Lorraine, CNRS, 54505 Vandœuvre-lès-Nancy, France. Electronic address: muriel.barberi@univ-lorraine.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a protocol to develop a syngeneic surgical glioblastoma model using F98 cells in Fischer F344 rats. This model recapitulates tumor growth, surgical resection, and recurrence observed in patients. We describe procedures for F98 cell preparation, stereotactic implantation, MRI-guided tumor resection, and longitudinal MRI monitoring. This protocol provides a clinically relevant platform to investigate post-resection tumor recurrence and evaluate therapeutic strategies targeting residual disease.

Indexed as

Brain NeoplasmsDisease Models, AnimalGlioblastomaNeoplasm Recurrence, LocalAnimalsCell Line, TumorHumansMagnetic Resonance ImagingRatsRats, Inbred F344Biotechnology and bioengineeringCancerClinical Protocol

Identifiers

PMID42001422
PMCPMC13098414

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.