SynthesisInternational urology and nephrology2026
Kidney transplant outcomes in patients aged ≥ 70 years: a systematic review and meta-analysis of multicenter or registry-based studies with future directions and a multicenter study proposal.
Synthesis in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundKidney transplantation in recipients aged ≥ 70 years is increasing, yet outcome data remain heterogeneous, with current evidence being limited to pooled results from single and multicenter studies. This study aims to investigate the impact of advanced age on patient survival as well as graft-related outcomes from multicenter and registry-based studies and to propose a multicenter study to bridge any identified research gap.
methodsThe PRISMA and the Cochrane Handbook were followed. This review included multicenter studies and registry-based comparative studies only, which are less prone to selection bias. Outcomes were analysed using risk ratios (RRs) at fixed time points, when applicable, with a random-effects Mantel-Haenszel model.
resultsFive multicenter studies including a total of 272,982 recipients, of whom 16,309 were aged ≥ 70 years, were included. Recipients aged ≥ 70 years had a lower overall and 5-year survival, RR = 0.87 (95% CI 0.77-0.99; p = 0.04, I
conclusionKidney transplantation in carefully selected recipients aged ≥ 70 years is associated with preserved graft survival and comparable early graft-related outcomes, but lower overall and 5-year survival, compared to those < 70 years of age. However, due to the limited number of studies included and substantial heterogeneity, future large multicenter studies including geriatric variables are required to determine the role of age on patient survival and graft-related outcomes.
trial registrationPROSPERO: CRD420261293247.
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