Evidence map›Paper›PMID 42001333›Full record

ArticleWorld journal of urology2026

Impact of continuous local anesthetic wound infiltration on postoperative outcomes following open radical cystectomy: a comprehensive evaluation.

François Crettenand, Alkiviadis Papagiannakis, Kevin Stritt, Nuno Grillo, Beat Roth, Sonia Rodrigues Dias, Jean-Daniel Rouvé, Catherine Blanc, Ilaria Lucca

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Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

François Crettenand *Department of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland. francois.crettenand@chuv.ch.
Alkiviadis Papagiannakis *Department of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
Kevin StrittDepartment of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
Nuno GrilloDepartment of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
Beat RothDepartment of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
Sonia Rodrigues DiasDepartment of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
Jean-Daniel RouvéDepartment of Anesthesiology, Lausanne University Hospital, University of Lausanne, Lausanne, 1011, Switzerland.
Catherine BlancDepartment of Anesthesiology, Lausanne University Hospital, University of Lausanne, Lausanne, 1011, Switzerland.
Ilaria LuccaDepartment of Urology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate continuous wound infiltration (CWI) as an alternative to thoracic epidural analgesia (TEA) for postoperative recovery after open radical cystectomy within an ERAS® pathway. MATERIALS AND

methodsRetrospective before–after cohort at a Swiss tertiary center using a prospectively maintained ERAS® database (TEA: Nov 2012–May 2016; CWI: Jun 2016–Mar 2024). Adults undergoing open cystectomy with extended pelvic lymphadenectomy and ileal conduit or neobladder were included (CWI = 154; TEA = 88). Outcomes were daily pain (VAS 0–10), nausea, opioid rescue (POD0–3), gastrointestinal recovery (first stool; tolerance of solid food), length of stay (LOS), and 90-day complications. Mixed-effects and multivariable models adjusted for prespecified covariates.

resultsPain scores were lower with TEA on POD0–3, whereas CWI had less postoperative nausea. CWI showed faster bowel recovery (first stool median 5 vs. 6 days, p = 0.02) and earlier tolerance of solid food (median 5 vs. 11 days, p < 0.001; adjusted β − 4.4 days, 95% CI − 6.8 to − 2.1). LOS was shorter with CWI (median 15 vs. 24 days, p < 0.001; adjusted β − 5.0 days, 95% CI − 9.1 to − 1.0). Early opioid rescue was more frequent with CWI, attenuating by POD3. No CWI catheter-related complications occurred.

conclusionWithin ERAS®, CWI with ropivacaine is a clinically acceptable alternative to TEA after open RC, trading slightly higher early pain for faster gastrointestinal recovery and a shorter LOS.

Indexed as

Anesthesia, LocalAnesthetics, LocalCystectomyPostoperative PainUrinary Bladder NeoplasmsAgedFemaleHumansLength of StayMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeAnesthetics, LocalBladder cancerCystectomyEnhanced recovery after surgeryPain managementPostoperative care

Identifiers

PMID42001333

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.