ArticleAnnals of Saudi medicine
Molecular characterization of Carbapenem-resistant Gram-negative bacilli associated with nosocomial infections in Hail, Saudi Arabia.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Direct-from-Specimen Detection of Major Carbapenemases by Carbapenem-Resistant K.N.I.V.O. Detection K-Set: Comparative Analysis of Accuracy and Turnaround Time.Pathogens (Basel, Switzerland) · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundCarbapenem-resistant Enterobacteriaceae (CRE) are listed as critical priority antibiotic-resistant pathogens by the World Health Organization.
objectiveThis study investigated the prevalence and the molecular mechanisms underlying carbapenem resistance among four clinically relevant Gram-negative bacterial species associated with nosocomial infections.
designSingle-centre cross-sectional study.
settingA tertiary hospital in Hail, Saudi Arabia.
methodsA total of 207 nosocomial gram-negative bacilli isolates were collected from December 2022 to July 2023. The isolates' identification and antimicrobial susceptibility testing (AST) were done using BD Phoenix M50. Isolates that showed resistance to one or more Carbapenemes agents in the antibiotic susceptibility test (AST) profile were further tested by a molecular method using Polymerase Chain Reaction (PCR) (Xpert Carba-R assay) for the detection of five most common Carbapenemases [
main outcome measuresIdentification of carbapenemase producers among Gram-negative bacteria associated with nosocomial infections. SAMPLE SIZE: 207 Gram-negative bacilli isolates.
resultsOf 207 GNB isolates, 162 were carbapenem-resistant, with
conclusionCarbapenemase-producing Gram-negative bacilli were prevalent among hospitalized patients in Hail, with bla LIMITATIONS: The lack of sufficient funding has impeded the expansion of this study to perform WGS on all isolates.
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