Evidence map›Paper›PMID 42001223›Full record

ArticlePest management science2026

Phytotoxic activity of grammicin produced by the fungus Xylaria grammica (Ascomycota) recovered from infected lesions on Handroanthus serratifolius (Bignoniaceae) leaves.

Debora Luiza Costa Barreto, Charles L Cantrell, Amber Callahan Reichley, Joanna Bajsa-Hirschel, Prabin Tamang, Zhiqiang Pan, T Casey Barickman, Pankaj Pandey, Amar G Chittiboyina, Shabana Iqrar Khan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Debora Luiza Costa BarretoDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Charles L CantrellNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture University, Oxford, MS, USA.
Amber Callahan ReichleyNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture University, Oxford, MS, USA.
Joanna Bajsa-HirschelNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture University, Oxford, MS, USA.ORCID https://orcid.org/0000-0001-7607-5808
Prabin TamangNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture University, Oxford, MS, USA.ORCID https://orcid.org/0000-0003-4994-5374
Zhiqiang PanNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture University, Oxford, MS, USA.
T Casey BarickmanNatural Products Utilization Research Unit, Agricultural Research Service, United States Department of Agriculture University, Oxford, MS, USA.
Pankaj PandeyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS, USA.ORCID https://orcid.org/0000-0001-9128-8254
Amar G ChittiboyinaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS, USA.
Shabana Iqrar KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS, USA.
Stephen Oscar DukeNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS, USA.ORCID https://orcid.org/0000-0001-7210-5168
Franck E DayanDepartment of Agricultural Biology, Colorado State University, Fort Collins, CO, USA.ORCID https://orcid.org/0000-0001-6964-2499
Catherine TraxlerDepartment of Agricultural Biology, Colorado State University, Fort Collins, CO, USA.ORCID https://orcid.org/0000-0002-6362-6735
Camila Rodrigues de CarvalhoDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Sonia Claudia do Nascimento de QueirozLaboratório de Resíduos e Contaminantes, Embrapa Meio Ambiente, Jaguariúna, Brazil.
Luiz Henrique RosaDepartamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe report the bioassay-guided isolation and identification of phytotoxic compounds from an extract of the fungus Xylaria grammica (Ascomycota), isolated from leaf lesions of seedlings of Handroanthus serratifolius (Bignoniaceae), from the Atlantic Rain Forest in Brazil. From the fungal crude extract, grammicin (1) and xylaric acid methyl ester (2) were purified and identified using one- and two-dimensional nuclear magnetic resonance and high-resolution mass spectrometry analysis.

resultsGrammicin exhibited activity against Lactuca sativa (lettuce) and Agrostis stolonifera (bentgrass) at 1 mg mL

conclusionsThis is the first report unveiling the phytotoxicity of grammicin, which could serve as a scaffold for developing more potent herbicides with improved physicochemical properties and without any potential for cytotoxicity. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Indexed as

BignoniaceaeHerbicidesXylarialesLactucaPlant LeavesHerbicidesbioherbicidefungigrammicinherbicidalnatural productXylaria

Identifiers

PMID42001223
PMCPMC13352324

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.