Evidence map›Paper›PMID 42001186›Full record

ArticleAlzheimer's research & therapy2026

Gamma low field magnetic stimulation ameliorates pathophysiological damage and cognitive impairments in AD mice.

Weiran Zheng, Duyan Geng, Alan Wang, Zhichao Li, Aoge Liu, Shuting Chen, Qiang Wang, Chi Su, Ziyi Yan, Yue Yin and 1 more

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In one paragraph

Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Weiran ZhengSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Duyan GengSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China. dygeng@hebut.edu.cn.
Alan WangAuckland Bioengineering Institute, University of Auckland, Auckland, 1010, New Zealand.
Zhichao LiShijiazhuang Dukon Medical Instruments Co., Ltd, Shijiazhuang, 050081, China.
Aoge LiuSchool of Health Science and Biomedical Engineering, Hebei University of Technology, Tianjin, 300130, China.
Shuting ChenSchool of Health Science and Biomedical Engineering, Hebei University of Technology, Tianjin, 300130, China.
Qiang WangSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Chi SuSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Ziyi YanSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Yue YinSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.
Guizhi XuSchool of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, China.

Funding

Hebei Province Provincial Science and Technology Programme Project International Science and Technology Co-operation Special Project 25292001DNational Key R&D Program of China 2022YFC2402203National Natural Science Foundation of China 52277230Science and Technology Cooperation Special Project of Shijiazhuang SJZZXB24006
6 · The paper itself

Abstract

backgroundThe normal functioning of gamma rhythms is crucial for maintaining brain health, while their abnormalities are closely associated with various neurological disorders, particularly Alzheimer's disease. Gamma stimulation modalities including auditory, visual, electrical, and strong magnetic approaches have all demonstrated potential therapeutic effects for AD, with substantial research findings continuously emerging. However, 40 Hz gamma low field magnetic stimulation(gamma-LFMS) remains unexplored.

methodsTo investigate this question, we applied pulsed magnetic fields with a magnetic field strength of 10 mT and frequency of 40 Hz (2 × 30 min/day) to 9-month-old APP/PS1 double transgenic AD model mice for 18 consecutive days, and evaluated changes in spatial memory capacity, hippocampal neural network characteristics, and amyloid protein 42 content in AD mice.

resultsGamma-LFMS significantly enhanced spatial memory performance in AD mice, increased theta-gamma phase-amplitude coupling and gamma band power in the hippocampal CA1 region, showed a trend toward desynchronization in low gamma, and effectively reduced hippocampal β-amyloid42 burden.

conclusionsThis study demonstrates for the first time that gamma-LFMS effectively ameliorates pathophysiological alterations and spatial memory deficits in AD mice. These findings address a critical knowledge gap regarding the effects of gamma-LFMS on AD pathology and provide a theoretical foundation for developing cost-effective home-based prevention and treatment devices applicable throughout the lifespan.

Indexed as

Alzheimer DiseaseCognitive DysfunctionGamma RhythmMagnetic Field TherapyAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalHippocampusMaleMaze LearningMiceMice, TransgenicPeptide FragmentsPresenilin-1Spatial MemoryAmyloid beta-Peptidesamyloid beta-protein (1-42)Amyloid beta-Protein PrecursorPeptide FragmentsPresenilin-1Alzheimer's diseaseAmyloid-beta 42CognitiveGamma low field magnetic stimulationHippocampal CA1 regionNeural network properties

Identifiers

PMID42001186
PMCPMC13220417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.