Evidence map›Paper›PMID 42001182›Full record

ArticleJournal of nanobiotechnology2026

A multifunctional ICAM1-directed MnO₂@ZIF8 nanoplatform with Tanshinone IIA synergistically reverses senescence and restores alveolar regeneration in septic lung injury.

Shan Lin, Xuefeng Ding, Xin Dang, Dachen Luo, Dan Cao, Zonglian Gong, Qingyuan Zhan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shan LinDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Xuefeng DingDepartment of Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Xin DangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Dachen LuoDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Dan CaoDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Zonglian GongDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, Sichuan, China.
Qingyuan ZhanDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Center for Respiratory Medicine, Friendship Hospital, Beijing, 100029, China. drzhanqy@163.com.

Funding

Key Project of the Affiliated Hospital of North Sichuan Medical College 2023ZD008Project of the Doctoral Initiation Fund 2023GC002, KYZC20240424Research Development Plan Project of Affiliated Hospital of North Sichuan Medical College 2024MPZK003Science and Technology Project of Nanchong 22SXQT0364Scientific Research and Development Program Project 2024PTZK008Sichuan Province Clinical Key Specialty Construction Project 2023GZZKP002
6 · The paper itself

Abstract

Sepsis-induced acute lung injury (ALI) is characterized by severe oxidative stress and senescence of alveolar type II epithelial cells (AECⅡ), yet effective therapies capable of reversing these pathological processes remain lacking. We developed a multifunctional ICAM1-targeted MnO

Indexed as

AbietanesAcute Lung InjuryCellular SenescenceIntercellular Adhesion Molecule-1Manganese CompoundsOxidesPulmonary AlveoliSepsisAlveolar Epithelial CellsAnimalsHumansMaleMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesAbietanesIntercellular Adhesion Molecule-1Manganese Compoundsmanganese oxideOxidesReactive Oxygen SpeciestanshinoneAcute Lung InjuryAlveolar Epithelial Cells Type IINanozymeSenescenceSepsis

Identifiers

PMID42001182
PMCPMC13251263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.