Evidence map›Paper›PMID 42001170›Full record

ArticleJournal of animal science and biotechnology2026

BMPER induces the adipogenic differentiation of fibro/adipogenic progenitors and promotes intramuscular fat deposition in chickens.

Ying Liu, Jianliang Liu, Xuan Sun, Xiuze Zhang, Tong Xing, Lin Zhang, Feng Gao, Liang Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying LiuCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China.
Jianliang LiuCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China.
Xuan SunCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China.
Xiuze ZhangCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, P.R. China.
Tong XingCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China.
Lin ZhangCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China.
Feng GaoCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China.
Liang ZhaoCollege of Animal Science and Technology, State Key Laboratory of Meat Quality Control and Cultured Meat Development, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, P.R. China. liang.zhao@njau.edu.cn.

Funding

Fundamental Research Funds for the Central Universities YDZX2023003Jiangsu Agriculture Science and Technology Innovation Fund CX (23)1016National Natural Science Foundation of China 32573161
6 · The paper itself

Abstract

backgroundFibro-adipogenic progenitors (FAPs) serve as the developmental origin of intramuscular adipocytes in skeletal muscle‌. Enhancing their adipogenic transition could increase intramuscular fat (IMF) deposition, thereby improving meat flavor in chickens‌. However, critical aspects of FAPs including their cellular composition, dynamic changes during skeletal muscle growth, and associated regulatory mechanisms remain poorly understood‌. Therefore, we comprehensively characterized FAPs in Langshan chickens from d 1 to d 98 using both in vivo and in vitro approaches combined with single-nucleus RNA sequencing (snRNA-seq) analysis.

resultsOur analysis of IMF contents and adipogenesis-related gene expression in the pectoralis major muscle of Langshan chickens revealed that the adipogenic properties of FAPs peaked at d 1, reached its lowest point at d 14, and subsequently increased until d 98. The snRNA-seq analysis successfully identified the population of FAPs along with their 5 subtypes including the pre-adipogenic, adipogenic, and fibrotic FAPs. The ratio of the pre-adipogenic subtype decreased from d 14 to d 98, which was reversely correlated with the changes of the adipogenic subtype, suggesting a differentiating process. Furthermore, RNA velocity and pseudo-trajectory analysis revealed that the initial FAPs had superior fibrotic capacity but decreased over time which contrasted with their enhanced adipogenic capacity with development. Notably, BMPER was identified as an important regulator for the adipogenic differentiation of FAPs, which was also confirmed by in vitro over-expression studies. In addition, the expression of BMPER in the adipogenic portion of FAPs was found to be highly conserved across human and mouse skeletal muscles.

conclusionsOur study provides the first comprehensive atlas of FAPs in the skeletal muscle of chickens and identifies BMPER as a key regulator for the adipogenic differentiation of FAPs. The findings will not only provide novel targets for breeding chickens with high IMF content but also offer significant insights into understanding the cell fate decision of FAPs under both physiological and pathological conditions across species.

Indexed as

Adipogenic progressionBMPERBroilersFibro/adipogenic progenitorssnRNA-seq

Identifiers

PMID42001170
PMCPMC13092164

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.