ArticleParasites & vectors2026
Long-term efficacy of fluralaner (Exzolt
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundChagas disease control relies primarily on vector control using pyrethroid insecticide sprays with residual action in domestic and peridomestic environments. However, the necessity for repeated applications and the development of pyrethroid resistance in some countries have undermined this strategy. Alternative control tools are needed, and host-targeted systemic insecticides offer an alternative approach by creating toxic blood meals for hematophagous vectors. In peridomestic settings, chickens are major blood meal sources for triatomines. This study evaluated the insecticidal activity of orally administered fluralaner (Exzolt
methodsSixteen non-breeding chickens (Gallus gallus domesticus) were randomized by weight into four groups: group 1, untreated control (n = 4); group 2, treated with two doses of 0.5 mg/kg fluralaner/Exzolt® (n = 4); group 3, treated with two doses of 2.5 mg/kg fluralaner/Exzolt® (n = 4); group 4, treated with two doses of 5.0 mg/kg fluralaner/Exzolt® (n = 4). To assess fluralaner (Exzolt®) efficacy, chickens were exposed to blood feeding by triatomines at baseline (day 0) and 1, 7, 14, 21, 28, 35, 56 and 77 days post-treatment. Mortality was monitored daily for up to 7 days after each feeding.
resultsTreatment with 0.5, 2.5 and 5.0 mg/kg of Exzolt® resulted in 100% insecticidal activity in triatomines for up to 14, 21 and 28 days post-treatment, respectively. The 2.5 and 5.0 mg/kg doses produced comparable insecticidal activity, both superior than that observed at 0.5 mg/kg.
conclusionsOral administration of fluralaner (Exzolt®) to chickens induces 100% insecticidal activity and maintains insecticidal efficacy against multiple triatomine species for up to 28 and 56 days post-treatment, respectively. These findings highlighting the potential of fluralaner as a complementary vector control strategy for Chagas disease in endemic areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.