Evidence map›Paper›PMID 42001083›Full record

ArticleJournal of cardiothoracic surgery2026

Computational fluid dynamics analysis for enlargement of the descending aorta after frozen elephant trunk implantation.

Hiroki Nakabori, Kenji Iino, Ai Sakai, Masaki Kitazawa, Hideyasu Ueda, Yoshitaka Yamamoto, Yukiko Yamada, Akira Murata, Hirofumi Takemura, Takahiro Kiwata

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In one paragraph

Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hiroki NakaboriDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan. n.hiroki@med.kanazawa-u.ac.jp.
Kenji IinoDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Ai SakaiDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Masaki KitazawaDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Hideyasu UedaDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Yoshitaka YamamotoDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Yukiko YamadaDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Akira MurataDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Hirofumi TakemuraDepartment of Cardiovascular Surgery, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Takahiro KiwataSchool of Mechanical Engineering, Kanazawa University, Kanazawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute type A aortic dissection (ATAAD) treated with total arch replacement (TAR) plus frozen elephant trunk (FET) can achieve favorable early remodeling; however, late enlargement of the distal descending aorta still occurs in some patients.

methodsStudy 1 included ATAAD patients who underwent TAR with FET between January 2015 and December 2023 and achieved complete false-lumen obliteration at the distal FET level. We identified cases with more than 5 mm enlargement at the distal FET level during follow-up and performed statistical analyses. Among these, patients with contrast-enhanced CT were analyzed using CFD. Study 2 used idealized aorta–stent graft models with different aorto-stent graft angles (AS angle) to isolate the hemodynamic effect of angulation.

resultsIn Study 1, larger AS angle was associated with subsequent aortic enlargement, and a cutoff around 38.3° suggested higher risk. CFD tended to show disturbed/recirculating flow along the lesser curvature in high-angle cases, with lower WSS and higher OSI at the distal FET level. In Study 2, increasing AS angle accentuated lesser-curvature flow disturbance and increased greater-curvature WSS; Pearson correlations suggested a positive association between AS angle and greater-curvature WSS/TAWSS.

conclusionsA larger AS angle may be associated with enlargement of the distal aorta after FET. Larger and more precise studies are warranted to validate these findings.

Indexed as

Aorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationHydrodynamicsBlood Vessel ProsthesisDissection, Ascending AortaDissection, Thoracic AortaFemaleHemodynamicsHumansMaleTomography, X-Ray ComputedAortic dissectionComputational fluid dynamicsFrozen elephant trunkOscillatory shear indexWall shear stress

Identifiers

PMID42001083
PMCPMC13231691

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.