ArticleEuropean radiology2026
Invisible neuronal damage in stroke-free, asymptomatic chronic middle cerebral artery occlusion: evidence from soma and neurite density imaging.
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveIn the study, we utilized soma and neurite density imaging (SANDI) to investigate stroke-free patients with unilateral middle cerebral artery (MCA) occlusion, with the goal of analyzing gray matter damage in both affected and contralateral hemispheres. MATERIALS AND
methodsThe study involved 59 patients with unilateral MCA occlusion and 35 control subjects. All participants underwent three-dimensional T1-weighted imaging and SANDI examination. Model fitting of SANDI data generated maps of the following parameters: soma signal fraction (f
resultsPatients with unilateral MCA occlusion demonstrate significantly reduced f
conclusionIn unilateral MCA occlusion patients with identified abnormalities, the affected brain regions encompass the sensorimotor integration system, language system, limbic-emotional and memory system, subcortical gray matter, and visual processing system. Importantly, the right-sided MCA occlusion patients often have damage to the hippocampus and parahippocampal gyrus, leading to cognitive deficits. KEY POINTS: Question For asymptomatic stroke-free patients with chronic unilateral MCA occlusion, is microstructural neuronal damage present and detectable by soma and neurite density imaging? Findings Soma and neurite density imaging detect reduced f
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