ArticleCommunications biology2026
Ferritin light-chain contributes to hair cells function and survival.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Iron is essential for cellular function, as it is required for oxygen transport and mitochondria oxidative respiration. However, uncoordinated regulation of intracellular iron can produce reactive oxygen species, calling for a tight homeostasis. Here, we examine the role of the iron-binding protein, ferritin, known to store intracellular iron, in the cochlea. Genetic ablation of the ferritin light-chain (Ftl) in mouse leads to two different phenotypes. A fraction of the homozygous mice has moderate to profound hearing loss (Ftl
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