ArticleNPJ Parkinson's disease2026
Wearable-sensor based walking and non-walking measures as progression markers in early to mid-stage Parkinson's disease.
Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Digital measures of walking and sedentariness may objectively quantify Parkinson's disease (PD) progression. We analyzed longitudinal wearable-sensor data to evaluate the sensitivity and specificity of digital walking and non-walking measures in ambulatory people with PD. We selected 26 individual and 6 composite measures with sufficient sensitivity and test-retest reliability in a development dataset (N = 171). Twenty measures showed significant within-participant changes, and 7 showed larger 2-year effect-size than gold-standard clinical measures in people with early-stage PD (N = 101, mean number of years since diagnosis [YSD], 2.2). Significant changes in non-walking and composite measures were detectable as early as 10 months. Twelve measures showed greater change in people with more advanced PD (N = 67; mean YSD 6.5) compared to matched non-PD individuals (N = 171). Sensitivity and specificity results indicate that measures capturing walking and especially non-walking behaviors hold promise as PD progression markers in early to mid-stage PD.
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