Evidence map›Paper›PMID 42000783›Full record

ArticleScientific reports2026

Non-severe burn injury leads to sustained molecular changes in the brain in a murine model.

Amira Allahham, Nutan Chaudhari, Sarah Walsh, Blair Z Johnson, Samantha Lodge, Drew Hall, Zhenjun Deng, Rongchang Yang, Monique J Ryan, Phillip E Melton and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amira AllahhamBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Nutan ChaudhariMolecular Therapy Laboratory, Personalized Medicine Centre, Murdoch University, Murdoch, WA, 6150, Australia.
Sarah WalshSchool of Medical, Molecular, and Forensic Science, ENDORIGINS Endometriosis Biobank, Murdoch University, King Edward Memorial Hospital, Perth, WA, 6008, Australia.
Blair Z JohnsonBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Samantha LodgeCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Murdoch, WA, 6150, Australia.
Drew HallCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Murdoch, WA, 6150, Australia.
Zhenjun DengDepartment of Dermatology, The First Affiliated Hospital, The Second Clinical Medical College, Shenzhen People's Hospital, Southern University of Science and Technology, Jinan University), Shenzhen, 518020, Guangdong, China.
Rongchang YangCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Murdoch, WA, 6150, Australia.
Monique J RyanCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Murdoch, WA, 6150, Australia.
Phillip E MeltonMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.
Jennifer RodgerSchool of Biological Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Fiona M WoodBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Luke WhileyCentre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Murdoch, WA, 6150, Australia.
Mark W FearBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Andrew W StevensonBurn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia. Andrew.stevenson@uwa.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paediatric burn patients, including those with non-severe burns, have an increased risk of admission to hospital for mental health conditions for many years after the burn, even in children too young at the time of the burn to remember the incident. This study aimed to investigate the long-term physiological impact of non-severe burn injuries and non-burn trauma (NBT) on the brain in mice to understand whether there is a sustained impact of such injuries on the brain that may be linked to the increased mental health morbidity observed in patients. Mice were exposed to either a non-severe burn injury, an excision injury of the same size (equivalent non-burn trauma), or a sham procedure. Behavioural tests were conducted at multiple timepoints to measure anxiety and depression-like behaviour. Mice were euthanised three months after the injury, and plasma and brain tissue, including the hippocampus and prefrontal cortex, were isolated and examined using RNA sequencing, mass spectrometry and nuclear magnetic resonance to identify transcriptomic and metabolomic changes. A significant change in behaviour was observed with an increase in sucrose consumption three months after injury in the burn group compared to sham. Significant changes in the transcriptome were identified in some brain regions at 3 months after burn trauma compared to the sham group. Differentially expressed genes associated with inflammatory and immune functions were identified in the burn group compared to controls. Significant changes were also observed in the lipid profile and tryptophan catabolites in the brain after burn trauma compared to sham. Sustained changes in the transcriptome and metabolome were identified in a mouse model of non-severe burns, supporting a likely sustained pro-inflammatory environment in the brain after this type of injury. The potential link between these changes and the poor long-term mental health outcomes observed in paediatric burn patients requires further investigation.

Indexed as

BrainBurnsAnimalsAnxietyBehavior, AnimalDepressionDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLTranscriptomeBurn injuryInflammationMental healthNeurodegenerationNon-severe burn injury

Identifiers

PMID42000783
PMCPMC13249875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.