Evidence map›Paper›PMID 42000711›Full record

ArticleNature communications2026

Cholecystokinin coordinates gonadotropin-dependent and independent pathways to orchestrate zebrafish gonadal development.

Hangyu Li, Faming Yuan, Hongwei Liang, Xiang Li, Shuo Zheng, Linlin Wang, Xiangchen Wu, Changyan Li, Xiangtong Zeng, Xuewen Rao and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hangyu Li *College of Fisheries, Huazhong Agricultural University, Wuhan, China.
Faming Yuan *College of Fisheries, Huazhong Agricultural University, Wuhan, China.
Hongwei Liang *Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture, Yangtze River Fisheries Research Institute, The Chinese Academy of Fisheries Sciences, Wuhan, China.
Xiang LiCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Shuo ZhengCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Linlin WangCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Xiangchen WuCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Changyan LiCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Xiangtong ZengCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Xuewen RaoCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Dandong HuangCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Zhixiu LiangCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Tianyi CaiCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Shaohua XuCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Xiangfeng QinCollege of Fisheries, Huazhong Agricultural University, Wuhan, China.
Xiangjiang LiuCollege of Fisheries, Huazhong Agricultural University, Wuhan, China. liuxiangjiang@mail.hzau.edu.cn.
Zhan YinShenzhen Research Institute, Ocean University of China, Shenzhen, China. zyin@ihb.ac.cn.
Guangfu HuCollege of Fisheries, Huazhong Agricultural University, Wuhan, China. huguangfu@mail.hzau.edu.cn.ORCID 0000-0003-3000-1920

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholecystokinin (CCK) is established as a critical regulator of teleost gonadal development, functioning not only as a follicle-stimulating-hormone-releasing hormone (FSH-RH) but also stimulating gonadal development through three distinct mechanisms. Specifically, (1) CCK directly activates pituitary lhb transcription via CCKBRb in a specific bi-hormonal subpopulation, and indirectly enhances hypothalamic gnrh3 expression to regulate LH synthesis and secretion. However, CCK's physiological role in LH regulation requires further investigation, and its effect may involve both direct and indirect mechanisms, including targeting a specific bi-hormonal subpopulation. (2) CCK exerts gonadotropin-independent control over primordial germ cell (PGC) proliferation during embryogenesis, evidenced by significantly reduced PGC numbers in cck1

Indexed as

CholecystokininGonadotropinsGonadsZebrafishZebrafish ProteinsAnimalsApoptosisCell ProliferationFemaleGene Expression Regulation, DevelopmentalGerm CellsGonadotropin-Releasing HormoneHypothalamic-Pituitary-Gonadal AxisLuteinizing HormoneMaleMeiosisCholecystokininGonadotropin-Releasing Hormonegonadotropin-releasing hormone-IIIGonadotropinsLuteinizing HormonePyrrolidonecarboxylic AcidReceptor, Cholecystokinin BZebrafish Proteins

Identifiers

PMID42000711
PMCPMC13275923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.