Evidence map›Paper›PMID 42000708›Full record

ArticleEuropean journal of neurology2026

Assessing Optic Nerve Involvement in Multiple Sclerosis Using Optical Coherence Tomography and Magnetic Resonance Imaging.

Gualco Alessandro, Boffa Giacomo, Razzetta Chiara, Lapucci Caterina, Cipriano Emilio, Nasone Lorenza, Sirito Tommaso, Al Qudsi Sabrina, Garbarino Sara, Saitta Laura and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gualco AlessandroDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0009-0008-5818-2552
Boffa GiacomoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0003-2220-9422
Razzetta ChiaraIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Lapucci CaterinaIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Cipriano EmilioDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.ORCID https://orcid.org/0000-0003-0304-0529
Nasone LorenzaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Sirito TommasoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Al Qudsi SabrinaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Garbarino SaraDepartment of Mathematics (DIMA), University of Genoa, Genoa, Italy.
Saitta LauraIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Campi CristinaIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Iester MicheleDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Cellerino MariaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.
Inglese MatildeDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

Funding

Ministry of University and Research (MUR), Italy FIS_00002258Ministry of University and Research (MUR), Italy PE0000006
6 · The paper itself

Abstract

backgroundOptic nerve involvement in Multiple Sclerosis (MS) can be detected with Optical Coherence Tomography (OCT) based on intereye difference (IED). We aimed to assess optic nerve involvement in a large real-world MS cohort applying the 2024 McDonald IED cut off criteria, and to investigate OCT-MRI concordance.

methodsOCT measurements of peripapillary-retinal-nerve-fiber-layer (pRNFL) and ganglion-cell-inner-plexiform-layer (GCIPL) thickness were analyzed in 740 MS patients. Clinical histories of optic neuritis (ON) were reviewed. Three-dimensional double inversion recovery MRI sequences for optic nerve assessment were available for 240 patients.

resultsThe IED cutoff (GCIPL ≥ 4 μm or pRNFL ≥ 6 μm) demonstrated 83% sensitivity and 55% specificity for identifying prior ON. In the MRI subgroup, it yielded 67% sensitivity and 83% specificity for detecting asymptomatic optic nerve lesions. MRI identified lesions in 46% of patients without a prior history of ON, whereas OCT-IED was positive in 40%, resulting in an overall OCT-MRI concordance of 77%. Among asymptomatic patients (n = 164), 25 were OCT-negative/MRI-positive (11 with bilateral optic nerve involvement) and 15 were OCT-positive/MRI-negative, mostly with isolated GCIPL or pRNFL asymmetry.

conclusionsThe 2024 McDonald IED cutoff demonstrates high sensitivity for prior ON but reduced sensitivity for subclinical optic nerve involvement. MRI appears slightly more sensitive, with both modalities providing complementary information on optic nerve pathology.

Indexed as

Magnetic Resonance ImagingMultiple SclerosisOptic NerveOptic NeuritisTomography, Optical CoherenceAdultFemaleHumansMaleMiddle AgedSensitivity and SpecificityMRImultiple sclerosisoptical coherence tomographyoptic nerveoptic neuritis

Identifiers

PMID42000708
PMCPMC13091724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.