ReviewCurrent opinion in microbiology2026
The case for exploring innate memory in Plasmodium infection.
Review in Current opinion in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In highly malaria-endemic areas, individuals can receive a bite from a Plasmodium-infected mosquito daily. Yet, most studies in the laboratory only assess a single infection, and our current understanding of malaria immunity does not fully explain how recurrent infections in the field impact pathogenesis and immunity upon re-infection. A growing body of literature suggests innate immune memory, in which epigenetic reprogramming regulates the immune response to sequential infections independently of adaptive immunity, may explain some of the dynamics of recurring Plasmodium infection in endemic areas. Here, we summarize the basic concepts of innate immune memory and findings that support its role in controlling Plasmodium infection and pathogenesis. Furthermore, we postulate that innate memory in non-immune cells, which is only beginning to be described in other disease systems, may have significant consequences in the context of the complex Plasmodium lifecycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.