Evidence map›Paper›PMID 42000606›Full record

ArticleJACC. Basic to translational science2026

JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes.

Xiaoyun Ji, Yifan Huang, Jinxi Wang, Zhifeng Dong, Rui Ni, Zijun Su, Dong Zheng, Guo-Chang Fan, Douglas L Jones, Long-Sheng Song and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaoyun JiNorthern Jiangsu Cardiovascular Disease Prevention and Treatment Research Institute, Jiangsu University, Zhenjiang, China; Department of Cardiovascular Medicine, Yancheng Third People's Hospital, Yancheng, China; International Genome Center, Jiangsu University, Zhenjiang, China; London Health Sciences Centre Research Institute, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Yifan HuangSchool of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Jinxi WangDivision of Cardiovascular Medicine, Department of Internal Medicine, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Zhifeng DongNorthern Jiangsu Cardiovascular Disease Prevention and Treatment Research Institute, Jiangsu University, Zhenjiang, China; Department of Cardiovascular Medicine, Yancheng Third People's Hospital, Yancheng, China.
Rui NiLondon Health Sciences Centre Research Institute, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Zijun SuLondon Health Sciences Centre Research Institute, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Dong ZhengCentre of Clinical Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, China.
Guo-Chang FanDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Douglas L JonesLondon Health Sciences Centre Research Institute, London, Ontario, Canada; Department of Physiology and Pharmacology, Western University, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada.
Long-Sheng SongDivision of Cardiovascular Medicine, Department of Internal Medicine, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Subrata ChakrabartiDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Jianxiang SongNorthern Jiangsu Cardiovascular Disease Prevention and Treatment Research Institute, Jiangsu University, Zhenjiang, China; Department of Cardiothoracic Surgery, Yancheng Third People's Hospital, Yancheng, China.
Zhaoliang SuNorthern Jiangsu Cardiovascular Disease Prevention and Treatment Research Institute, Jiangsu University, Zhenjiang, China; Department of Cardiovascular Medicine, Yancheng Third People's Hospital, Yancheng, China; International Genome Center, Jiangsu University, Zhenjiang, China. Electronic address: szl30@ujs.edu.cn.
Tianqing PengNorthern Jiangsu Cardiovascular Disease Prevention and Treatment Research Institute, Jiangsu University, Zhenjiang, China; Department of Cardiovascular Medicine, Yancheng Third People's Hospital, Yancheng, China; London Health Sciences Centre Research Institute, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada; Department of Medicine, Western University, London, Ontario, Canada. Electronic address: tpeng2@uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Junctophilin-2 (JP2) and junctin (JCN) are key proteins in maintaining calcium homeostasis in cardiomyocytes. Both are reduced in diseased hearts while overexpression of JP2 mitigates heart failure. This study demonstrates that JP2 and JCN are reduced in cardiomyocytes under stress, leading to intracellular calcium dysregulation and subsequent cell death. JP2 binds JCN, thereby blocking muscle ring finger protein-1 (MURF1)-JCN interaction and subsequently preventing MURF1-mediated JCN ubiquitination and degradation in cardiomyocytes. Thus, JP2 overexpression and MURF1 inhibition similarly preserve JCN protein and attenuate myocardial injury and remodeling, and improve myocardial function in preclinical animal models of lipid overload-induced cardiomyopathy and transverse aortic constriction-induced heart failure. Disruption of the JP2-JCN axis represents an important mechanism underlying heart disease and may serve as a potential therapeutic target for cardiac protection.

Indexed as

cardiomyocytejunctinjunctophilin-2MURF1ubiquitination

Identifiers

PMID42000606
PMCPMC13098515

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.