Evidence map›Paper›PMID 42000319›Full record

ArticleEBioMedicine2026

Genome-wide association studies of brain diffusion kurtosis imaging phenotypes.

Jilian Fu, Jianhua Wang, Hui Xue, Meiyun Wang, Bing Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Quan Zhang and 36 more

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Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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46 authors.

Jilian FuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Jianhua WangDepartment of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Hui XueDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Meiyun WangDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, 450003, Zhengzhou, China; Biomedical Institute, Henan Academy of Sciences, 450199, Zhengzhou, China.
Bing ZhangDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, 210008, Nanjing, China.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Shijun QiuDepartment of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 510405, Guangzhou, China.
Zuojun GengDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, China.
Guangbin CuiFunctional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, 710038, Xi'an, China.
Quan ZhangDepartment of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, 300162, Tianjin, China.
Yongqiang YuDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, 230022, Hefei, China.
Weihua LiaoDepartment of Radiology, Xiangya Hospital, Central South University, 410008, Changsha, China; Molecular Imaging Research Center of Central South University, 410008, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008 Changsha, China.
Bo GaoDepartment of Radiology, The Affiliated Hospital of Guizhou Medical University, 550004 Guiyang, China; Department of Radiology, Yantai Yuhuangding Hospital, 264000, Yantai, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, 310009 Hangzhou, China.
Tong HanDepartment of Radiology, Tianjin Huanhu Hospital, 300350, Tianjin, China.
Zhenwei YaoDepartment of Radiology, Huashan Hospital, Fudan University, 200040, Shanghai, China.
Mulin Jun LiDepartment of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, 300070, Tianjin, China.
Feng LiuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Meng LiangSchool of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, 300203, Tianjin, China.
Sijia WangDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Qiang XuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Jiayuan XuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China.
Peng ZhangDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Wei LiDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Dapeng ShiDepartment of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, 450003, Zhengzhou, China.
Caihong WangDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.
Su LuiDepartment of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, 610041, Chengdu, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, 610041 Chengdu, China.
Zhihan YanDepartment of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 325027, Wenzhou, China.
Feng ChenDepartment of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), 570311, Haikou, China.
Jing ZhangDepartment of Magnetic Resonance, Lanzhou University Second Hospital, 730030, Lanzhou, China; Gansu Province Clinical Research Center for Functional and Molecular Imaging, 730030, Lanzhou, China.
Jiance LiDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, China.
Wen ShenDepartment of Radiology, Tianjin First Center Hospital, 300192, Tianjin, China.
Yanwei MiaoDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, 116011, Dalian, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University, 250012, Jinan, China.
Junfang XianDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, China.
Jia-Hong GaoCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, 100871, Beijing, China.
Xiaochu ZhangDivision of Life Science and Medicine, University of Science & Technology of China, 230027, Hefei, China.
Kai XuDepartment of Radiology, The Affiliated Hospital of Xuzhou Medical University, 221006, Xuzhou, China.
Xi-Nian ZuoDevelopmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China; Institute of Psychology, Chinese Academy of Sciences, 100101, Beijing, China.
Longjiang ZhangDepartment of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, 210002, Nanjing, China.
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.
Wen QinDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China. Electronic address: wayne.wenqin@gmail.com.
Hui ZhangDepartment of Radiology, The First Hospital of Shanxi Medical University, 030001, Taiyuan, China. Electronic address: zhanghui_mr@163.com.
Chunshui YuDepartment of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, 300052, Tianjin, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 200031, Shanghai, China. Electronic address: chunshuiyu@tmu.edu.cn.
CHIMGEN Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs an extension of diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI) quantifies non-Gaussian water diffusion and has been applied to explore brain disorders. However, the genetic architecture of brain DKI phenotypes remains unknown.

methodsHere, we estimated heritability and conducted genome-wide association studies (GWASs) for 804 DKI phenotypes across 188 brain structures in 4183 participants. To determine whether DKI-GWASs provides genetic insights beyond DTI-GWASs, we compared results from 804 DKI-GWASs and 752 DTI-GWASs in the same cohort. To clarify the biological significance of DKI phenotypes, we examined associations between DKI phenotypes and brain health-related outcomes within the CHIMGEN, and explored associations between polygenic risk scores (PRSs) of DKI phenotypes and mental disorders in the UK Biobank.

findingsOf 804 DKI phenotypes, 275 showed significant heritability (P < 0.05; h

interpretationThis study delineates the genetic architecture of brain DKI phenotypes, identifies complementary genetic insights into brain microstructure, and provides biologically relevant endophenotypes for investigating neural mechanisms underlying brain disorders.

fundingNational Natural Science Foundation of China, National Key Research and Development Program of China, Tianjin Key Medical Discipline Construction Project, and Tianjin Natural Science Foundation.

Indexed as

BrainDiffusion Tensor ImagingGenome-Wide Association StudyPhenotypeFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedPolymorphism, Single NucleotideBrain health-related outcomesDiffusional kurtosis imagingDiffusion tensor imagingGenome-wide association analysisMental disorders

Identifiers

PMID42000319
PMCPMC13099350

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