ReviewTrends in genetics : TIG2026
Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution.
Review in Trends in genetics : TIG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond susceptibility results: understanding the clinical and diagnostic burden of bacterial heteroresistance.Molecular biology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Antibiotic response phenotypes have traditionally been classified as either sensitive or resistant. However, accumulating evidence indicates that bacterial responses to antibiotics are far more heterogeneous than previously appreciated. A growing set of new descriptors-including antibiotic persistence, tolerance, heteroresistance, resilience, and perseverance-has been introduced to capture noncanonical antibiotic phenotypes, which are widespread in bacteria and recognized as a cause of treatment failure. Although defined by different criteria, these phenotypes all converge on the heterogeneous nature of bacterial antibiotic responses. In this review, we focus on the heterogeneity-causing mechanisms embedded in genome maintenance, transcription, and translation; discuss how within-host evolved mutations can modulate regulatory stochasticity and shift population dynamics in ways that favor bacterial propagation; and highlight key future directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.