Slow PP

Tyler L Dangerfield, Ingrid Marko, Kenneth A Johnson

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyler L DangerfieldDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.

Ingrid MarkoDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.

Kenneth A JohnsonDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA. Electronic address: kajohnson@utexas.edu.

Funding

Dynamics of Hepatis C viral RNA-dependent RNA replicationR01AI110577 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI JOHNSON, KENNETH ALLEN · 2015 to 2018

$1.8M

NIAID NIH HHS R01 AI110577

6 · The paper itself

Abstract

Viral RNA-dependent RNA polymerases (RdRps) must balance replication speed with fidelity, preserving genome integrity while permitting enough variability for viral adaptation. The SARS-CoV-2 RdRp complex (non-structural protein 12/7/8) achieves this through the interplay of its intrinsic replication fidelity and a potential proofreading exonuclease complex (NSP10/14). Here, we comprehensively quantify the intrinsic fidelity of the SARS-CoV-2 RdRp through direct pre-steady-state kinetic analyses of nucleotide incorporation across all possible templating bases paired with incoming nucleotides. We discovered substantial variation in discrimination against mismatches ranging from one error in 10

Indexed as

Coronavirus RNA-Dependent RNA PolymeraseDiphosphatesRNA-Dependent RNA PolymeraseSARS-CoV-2HumansKineticsMutationRNA ReplicationRNA, ViralVirus ReplicationCoronavirus RNA-Dependent RNA PolymeraseDiphosphatesRNA-Dependent RNA PolymeraseRNA, Viralmismatch incorporationpre-steady-state kineticspyrophosphate releasereplication fidelityRNA-dependent RNA polymeraseSARS-CoV-2

Identifiers

PMID41999896

DOI10.1016/j.jbc.2026.111457

PMCPMC13208697

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.