Evidence map›Paper›PMID 41999681›Full record

ArticleThe journal of nutrition, health & aging2026

Dietary total antioxidant capacity alleviates inflammatory bowel disease-related surgery, gastrointestinal cancer, and mortality risks among middle-aged and older individuals.

Tian Fu, Lintao Dan, Sidan Wang, Xing Wu, Jiangwei Sun, Shuai Yuan, Alicja Wolk, Jonas F Ludvigsson, Xiaoyan Wang, Susanna C Larsson and 2 more

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Article in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Tian FuDepartment of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Postdoctoral Station of Clinical Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.
Lintao DanDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Sidan WangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Xing WuDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Jiangwei SunDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Shuai YuanDepartment of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, United States.
Alicja WolkUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jonas F LudvigssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden.
Xiaoyan WangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Susanna C LarssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. Electronic address: susanna.larsson@ki.se.
Jie ChenDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Postdoctoral Station of Clinical Medicine, the Third Xiangya Hospital, Central South University, Changsha, China; Xiangya School of Public Health, Central South University, Changsha, China. Electronic address: med_chenjie@csu.edu.cn.
Xue LiDepartment of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address: xueli157@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the association between dietary total antioxidant capacity (TAC) and the risks of clinical outcomes, including surgery, gastrointestinal cancer, and mortality, among middle-aged and older individuals with IBD.

designNationwide prospective cohort study. SETTING AND

participantsWe included middle-aged and older participants with IBD when recruited in the UK Biobank. MEASUREMENTS: Dietary TAC was calculated by the oxygen radical absorbance capacity from the food by repeated dietary recalls. The outcomes representing IBD prognosis include IBD-related surgery, gastrointestinal cancer, and death events. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazard models. Polymorphism of antioxidant-related enzymes genes was ascertained via genotype data.

resultsWith a median follow-up period of 10.9 years, we documented 174 cases of IBD-related surgery, 52 gastrointestinal cancer, and 189 death events among 2487 IBD participants. Compared to the lowest quartile of dietary TAC, participants in the highest quartile presented lower risks of IBD-related surgery (HR 0.53; 95% CI 0.34-0.84; P-trend = 0.005) and all-cause mortality (HR 0.61; 95% CI 0.39-0.96; P-trend = 0.014). Compared to the lowest decile, participants in the higher deciles of dietary TAC had a lower risk of gastrointestinal cancer (HR 0.39; 95% CI 0.19-0.83; P = 0.014). We also found genetic variants in catalase gene CAT and antioxidant transporter gene SLC2A14 modified the association between dietary TAC and IBD prognosis.

conclusionsHigher dietary TAC was associated with better prognosis of middle-aged and older individuals with IBD, including lower risk of related surgery, gastrointestinal cancer, and all-cause mortality, suggesting the importance of adherence to high-TAC diet in IBD management.

Indexed as

AntioxidantsDietGastrointestinal NeoplasmsInflammatory Bowel DiseasesAgedFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsUnited KingdomAntioxidantsDietary total antioxidant capacityGastrointestinal cancerInflammatory bowel diseaseMortalitySurgery

Identifiers

PMID41999681
PMCPMC13098422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.