Evidence map›Paper›PMID 41999632›Full record

ArticleThe Journal of infectious diseases2026

Maternal Cytomegalovirus Serology Results by Geographic Region in a Large Multicenter US Study.

Brenna L Hughes, Cora MacPherson, Dwight J Rouse, George R Saade, Mara J Dinsmoor, Uma M Reddy, Robert Pass, Donna Allard, Gail Mallett, Rebecca G Clifton and 16 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Brenna L HughesDepartments of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0001-8950-1204
Cora MacPhersonThe George Washington University Biostatistics Center, Washington, DC, USA.
Dwight J RouseDepartments of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, USA.
George R SaadeDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA.
Mara J DinsmoorDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-4643-8871
Uma M ReddyThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Robert PassDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-2029-0247
Donna AllardDepartments of Obstetrics and Gynecology, Brown University, Providence, Rhode Island, USA.
Gail MallettDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, USA.
Rebecca G CliftonThe George Washington University Biostatistics Center, Washington, DC, USA.
Cynthia Gyamfi-BannermanDepartment of Obstetrics and Gynecology, Columbia University, NewYork, New York, USA.
Michael W VarnerDepartment of Obstetrics and Gynecology, The University of Utah Health Sciences Center, Salt Lake City, Utah, USA.ORCID 0000-0001-9455-3973
William H GoodnightDepartment of Obstetrics and Gynecology, The University of North Carolina at Chapel Hill, Chapel Hill, Chapel Hill, North Carolina, USA.
Alan T N TitaDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-7244-9056
Maged M CostantineDepartment of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4076-469X
Geeta K SwamyDepartment of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA.
Kent D HeyborneDepartment of Obstetrics and Gynecology, The University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
Edward K ChienDepartment of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, Ohio, USA.
Suneet P ChauhanDepartment of Obstetrics and Gynecology, Children's Memorial Hermann Hospital, Houston, Texas, USA.
Yasser Y El-SayedDepartment of Obstetrics and Gynecology, Stanford University, Stanford, California, USA.
Brian M CaseyDepartment of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Samuel ParryDepartment of Obstetrics and Gynecology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hyagriv N SimhanDepartment of Obstetrics and Gynecology, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Peter G NapolitanoDepartment of Obstetrics and Gynecology, Madigan Army Medical Center, Joint Base Lewis-McChord, Washington, USA.
George A MaconesDepartment of Obstetrics and Gynecology, University of Texas at Austin, Austin, Texas, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
NICHD Maternal Fetal Medicine Units NetworkU10HD040500 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI ROUSE, DWIGHT J · 2001 to 2015
$7.5M
Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Noelia Milena Modad Zork · 2016 to 2026
$3.6M
NICHD Maternal Fetal Medicine Units NetworkUG1HD087192 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Lorraine Dugoff · 2016 to 2026
$3.6M
NICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040544 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI Kelly S Gibson, Angela C. Ranzini · 2016 to 2026
$3.5M
Maternal-Fetal Medicine Units Network -- The Northwestern Study CenterUG1HD040512 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Lynn M Yee · 2016 to 2026
$3.4M
NICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040500 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI DWIGHT J ROUSE · 2016 to 2026
$3.4M
UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical CentersUG1HD034208 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Torri D Metz · 2016 to 2026
$3.4M
NICHD Maternal Fetal Medicine Units NetworkUG1HD027915 · NICHD · OHIO STATE UNIVERSITY · PI Maged Costantine · 2016 to 2026
$3.3M
UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical StudiesUG1HD040560 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI John M Thorp · 2016 to 2026
$3.3M
CSL Behring, IncEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1TR000040NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1TR001873NICHD NIH HHS U10 HD040500NICHD NIH HHS U24 HD036801NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034116NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD040500NICHD NIH HHS UG1 HD040512NICHD NIH HHS UG1 HD040544NICHD NIH HHS UG1 HD040545NICHD NIH HHS UG1 HD040560NICHD NIH HHS UG1 HD053097NICHD NIH HHS UG1 HD068258NICHD NIH HHS UG1 HD068268NICHD NIH HHS UG1 HD068282NICHD NIH HHS UG1 HD087192NICHD NIH HHS UG1 HD087230
6 · The paper itself

Abstract

Congenital cytomegalovirus (CMV) infection, due to both nonprimary and primary maternal infection, affects nearly 1% of neonates. In conducting a randomized trial of hyperimmune globulin for prevention of congenital CMV infection, we screened over 200,000 pregnancies across the United States for evidence of prior or primary CMV infection and evaluated their geographic variation. Although the majority were seropositive, seroprevalence and primary infection risk varied significantly by geographic region, with seroprevalence the highest (88%) and primary infection (0.2%) the lowest in the Southwest. This variation in seroprevalence by geography may inform planning of public health measures to decrease congenital CMV.

Indexed as

Antibodies, ViralCytomegalovirusCytomegalovirus InfectionsPregnancy Complications, InfectiousFemaleHumansInfant, NewbornPregnancySeroepidemiologic StudiesUnited StatesAntibodies, Viraladverse pregnancy outcomescytomegalovirus hyperimmune globulin

Identifiers

PMID41999632
PMCPMC13159563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.