Pmpcb modulates zebrafish neurogenesis and stress resistance via regulating mitochondria metabolism and function.

YuanYuan Jing, Hui Peng, ZhiPeng Tai, GuoLiang Li, Jing-Xia Liu

Abstract read

In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Disrupted Copper Homeostasis and Impaired Retinal Development Caused byAnimals : an open access journal from MDPI · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

YuanYuan JingCollege of Fisheries, Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, China.

Hui PengCollege of Fisheries, Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, China.

ZhiPeng TaiCollege of Fisheries, Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, China.

GuoLiang LiCollege of Informatics, Agricultural Bioinformatics Key Laboratory of Hubei Province, Hubei Engineering Technology Research Center of Agricultural Big Data, Huazhong Agricultural University, Wuhan, 430070, China.

Jing-Xia LiuCollege of Fisheries, Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, China. ichliu@mail.hzau.edu.cn.

Funding

Biological Breeding-National Science and Technology Major Project 2023ZD04065the National Key R&D Program of China 2022YFF1000302

6 · The paper itself

Abstract

Pmpcb (peptidase, mitochondrial processing beta subunit) gene encodes the catalytic subunit of mitochondrial processing peptidase, and its mutation is associated with human multiple mitochondrial dysfunction syndrome type 6 (MMDS6), presenting with severe neurodegenerative lesions clinically. Nonetheless, the potential molecular mechanisms underlying pmpcb deficiency induced abnormal development of the central nervous system (CNS) and the related diseases have not been fully elucidated. In this study, we found that zebrafish larvae with a functional deficiency of pmpcb (pmpcb

Indexed as

MitochondriaNeurogenesisStress, PhysiologicalZebrafishZebrafish ProteinsAnimalsApoptosisEndoplasmic Reticulum StressLarvaMembrane Potential, MitochondrialNeuronsReactive Oxygen SpeciesWnt Signaling PathwayReactive Oxygen SpeciesZebrafish ProteinsApoptosisCNSER stressMitochondriapmpcbWNT

Identifiers

PMID41999531

DOI10.1007/s12035-026-05875-z

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.