Evidence map›Paper›PMID 41999395›Full record

ArticleVirchows Archiv : an international journal of pathology2026

FGFR1 mutations identified in FOXL2-wild type ovarian adult granulosa cell tumors are not present in testicular counterparts: Re-analysis of a multi-institutional series.

Costantino Ricci, Dario de Biase, Thais Maloberti, Agnese Orsatti, Thomas M Ulbright, Muhammad T Idrees, Esther Oliva, Kristine Cornejo, João Lobo, Kvetoslava Michalova and 11 more

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Costantino Ricci *DIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Pathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0001-7254-4195
Dario de Biase *Solid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-0609-8817
Thais MalobertiSolid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-8306-4653
Agnese OrsattiDIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Pathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy.ORCID http://orcid.org/0009-0005-8560-1925
Thomas M UlbrightDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W. 11 , Room 4080, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0002-7828-2496
Muhammad T IdreesDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W. 11 , Room 4080, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0001-6611-6389
Esther OlivaDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7355-4301
Kristine CornejoDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9490-8583
João LoboDepartment of Pathology, Portuguese Oncology Institute of Porto (IPOP), Porto, Portugal.ORCID http://orcid.org/0000-0001-6829-1391
Kvetoslava MichalovaDepartment of Pathology, Faculty of Medicine in Plzeň, Charles University, Bioptical Laboratory, Ltd, Plzeň, Czech Republic.ORCID http://orcid.org/0000-0003-3231-6870
Maria Rosaria RaspolliniDepartment of Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.ORCID http://orcid.org/0000-0001-6630-4881
Sean R WilliamsonPathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3898-1460
Geert J L H van LeendersDepartment of Pathology, Erasmus Medical Center, Erasmus University, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0003-2176-9102
Chia-Sui KaoPathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-6609-2567
Fiona MacleanDouglass Hanly Moir Pathology, Macquarie Park, Australia.ORCID http://orcid.org/0000-0002-6468-2368
Ankur R SangoiDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0874-8964
Adeboye O OsunkoyaDepartments of Pathology and Urology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-5712-8134
Michelangelo FiorentinoDIAP-Dipartimento Interaziendale Di Anatomia Patologica Di Bologna, Pathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-1749-150X
Antonio De LeoSolid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-3761-5135
Giovanni TalliniSolid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-0113-6682
Andres Martin AcostaDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W. 11 , Room 4080, Indianapolis, IN, 46202, USA. anmaacos@iu.edu.ORCID http://orcid.org/0000-0003-0164-5911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testicular adult granulosa cell tumors (AGCTs) are rare and show several clinical, pathological, and molecular differences with their ovarian counterparts. FOXL2 p.Cys134Trp, the ubiquitous molecular driver of ovarian AGCTs, is infrequent (~ 7%) in testicular AGCTs. Recently, FGFR1 hotspot mutations were reported as a potentially "alternative molecular driver" in FOXL2-wild type (WT) ovarian AGCTs. A systematic assessment of FGFR1 status has not been performed in testicular AGCTs. Recently, our group analyzed a series of twenty testicular AGCTs using two NGS panels that lacked coverage of FGFR1. Among twelve cases analyzed successfully, none harbored pathogenic FOXL2 variants. In this study, we reassessed the tumors from our prior series with an NGS panel that covers FGFR1. Among the 14 tumors (70%) that were sequenced successfully, none harbored pathogenic FGFR1 variants. Considering the AGCTs assessed in this study and those previously reported in the literature, none of the 24 tumors analyzed to date have shown pathogenic FGFR1 variants. The present study reinforces the concept that testicular sex cord-stromal tumors classified as AGCTs are different from ovarian counterparts.

Indexed as

FGFR1FGFR1 mutationsFOXL2FOXL2 mutationsNGSOvarian adult granulosa cell tumorTesticular adult granulosa cell tumor

Identifiers

PMID41999395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.