Evidence map›Paper›PMID 41999375›Full record

ArticleJACC. Asia2026

Design of MOSAAIC (Multi-Ethnic Observational Study in American Asian and Pacific Islander Communities).

Jiyoung Ahn, Habibul Ahsan, Garnet L Anderson, Briseis Aschebrook-Kilfoy, Danny Beery, William Carrick, Juan C Celedón, K C Gary Chan, Yu Chen, Lan N Ðoàn and 40 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Jiyoung AhnNYU Grossman School of Medicine, New York, New York, USA.
Habibul AhsanUniversity of Chicago, Chicago, Illinois, USA.
Garnet L AndersonFred Hutchinson Cancer Center, Seattle, Washington, USA.
Briseis Aschebrook-KilfoyUniversity of Chicago, Chicago, Illinois, USA.
Danny BeeryFred Hutchinson Cancer Center, Seattle, Washington, USA.
William CarrickFred Hutchinson Cancer Center, Seattle, Washington, USA.
Juan C CeledónUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
K C Gary ChanUniversity of Washington, Seattle, Washington, USA.
Yu ChenNYU Grossman School of Medicine, New York, New York, USA.
Lan N ÐoànNYU Grossman School of Medicine, New York, New York, USA.
Carolyn Y FangFox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
James S FloydUniversity of Washington, Seattle, Washington, USA.
Richard B HayesNYU Grossman School of Medicine, New York, New York, USA.
Victor HendersonStanford University, Stanford, California, USA.
Yuling HongNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Electronic address: yuling.hong@nih.gov.
Ann W HsingStanford University, Stanford, California, USA.
Li HsuFred Hutchinson Cancer Center, Seattle, Washington, USA.
Frank B HuHarvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jingyu Linna JinUniversity of Washington, Seattle, Washington, USA.
Esther M JohnStanford University, Stanford, California, USA.
Alka M KanayaUniversity of California-San Francisco, San Francisco, California, USA.
Robert C KaplanAlbert Einstein College of Medicine, Bronx, New York, USA. Electronic address: Robert.kaplan@einsteinmed.edu.
Muhammad G KibriyaUniversity of Chicago, Chicago, Illinois, USA.
Karen KimPenn State College of Medicine, Hershey, Pennsylvania, USA.
Clete KushidaStanford University, Stanford, California, USA.
Johanna W LampeFred Hutchinson Cancer Center, Seattle, Washington, USA.
ShangJu LiFred Hutchinson Cancer Center, Seattle, Washington, USA.
Ying LuStanford University, Stanford, California, USA.
Grace X MaLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Marjorie K L M MauJohn A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA.
Alika K MaunakeaJohn A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA.
Jason A MendozaFred Hutchinson Cancer Center, Seattle, Washington, USA.
Marian L NeuhouserFred Hutchinson Cancer Center, Seattle, Washington, USA.
Jonathan D NewmanNYU Grossman School of Medicine, New York, New York, USA.
Michelle C OddenStanford University, Stanford, California, USA.
Latha PalaniappanStanford University, Stanford, California, USA.
S Lani ParkUniversity of Hawaii Cancer Research Center, Honolulu, Hawaii, USA.
Fornessa RandalPenn State College of Medicine, Hershey, Pennsylvania, USA.
Isaac C RhewUniversity of Washington, Seattle, Washington, USA.
Stephanie SantosNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Elsayed Z SolimanWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Bharat ThyagarajanUniversity of Minnesota, Minneapolis, Minnesota, USA.
Jenny Hsin-Chun TsaiUniversity of Washington, Seattle, Washington, USA.
Trang VoPhamFred Hutchinson Cancer Center, Seattle, Washington, USA.
Paul WangStanford University, Stanford, California, USA.
Emily WionFred Hutchinson Cancer Center, Seattle, Washington, USA.
Ye YanNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Stella S YiNYU Grossman School of Medicine, New York, New York, USA.
Lin ZhuLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
MOSAAIC Investigators

Funding

Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) Mental Health Administrative SupplementU24HL169645 · NHLBI · FRED HUTCHINSON CANCER CENTER · PI GARNET L. ANDERSON, Kwun Chuen Gary Chan · 2023 to 2026
$28.9M
Asian American Community Cohort and Engagement Study (ACCESS)UH3HL170034 · NHLBI · RESEARCH INST OF FOX CHASE CAN CTR · PI Carolyn Y. Fang, Frank B Hu · 2025 to 2026
$1.4M
The Pacific Ocean Native Observational (PONO) Health Legacy StudyUH3HL169657 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Marjorie K. Leimomi Mala Mau, Alika Keolaokalani Maunakea · 2025 to 2026
$1.3M
Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)UH3HL169648 · NHLBI · STANFORD UNIVERSITY · PI Ann Hsing, Clete A Kushida · 2025 to 2026
$1.2M
The Pacific Ocean Native Observational (PONO) Health Legacy StudyUG3HL169657 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI MAU, MARJORIE K. LEIMOMI MALA, MAUNAKEA, ALIKA KEOLAOKALANI · 2023 to 2024
$1.2M
Asian American Prevention Research: A Populomics Epidemiology Cohort (ARISE)UG3HL169648 · NHLBI · STANFORD UNIVERSITY · PI HSING, ANN, KUSHIDA, CLETE A · 2023 to 2024
$1.2M
META - Mentor, Educate, Train, Advocate: Patient Oriented Researchers in Cardiometabolic DiseaseK24HL150476 · NHLBI · STANFORD UNIVERSITY · PI Latha P Palaniappan · 2020 to 2026
$846k
NHLBI NIH HHS K24 HL150476NHLBI NIH HHS U24 HL169645NHLBI NIH HHS UG3 HL169648NHLBI NIH HHS UG3 HL169657NHLBI NIH HHS UH3 HL169648NHLBI NIH HHS UH3 HL169657NHLBI NIH HHS UH3 HL170034
6 · The paper itself

Abstract

backgroundAsian American (AsA) and Native Hawaiian and Pacific Islander (NHPI) populations are underrepresented in U.S. health studies.

objectivesThe MOSAAIC (Multi-ethnic Observational Study in American Asian and Pacific Islander Communities) is a cohort study designed to improve understanding of disparities in cardiovascular disease and other health conditions affecting AsA and NHPI groups.

methodsThrough broad eligibility criteria and outreach tailored to each study community, MOSAAIC will include 11,500 adults aged 18+ years living in 5 field center regions: New York, Philadelphia, Chicago, San Francisco Bay Area, and Honolulu. The protocol specifies sample-size targets to allow valid comparisons among persons having personal or family origins in 4 geographically defined regions, including East Asia (the largest groups being Chinese and Korean), South Asia (Indian), Southeast Asia (Vietnamese and Filipino) and Oceania (NHPI). Measurements to be obtained at an in-person examination include clinical laboratory tests, medical history, medication use, spirometry, cognitive and physical function, anthropometry, and electrocardiogram. Surveys in multiple languages to assess medical, behavioral, lifestyle, social and environmental influences on health were developed by a multistep process to ensure equivalency between translations and cultural appropriateness. Biospecimens are stored for future studies. Long-term follow-up will be conducted to ascertain and adjudicate major health events including myocardial infarction, stroke, heart failure, and mortality.

conclusionsThe National Institutes of Health established MOSAAIC as a resource for wide-ranging epidemiologic investigation of factors related to cardiometabolic, pulmonary, or mental health in persons of diverse AsA and NHPI background.

Indexed as

cardiovascularcohort studyprevention

Identifiers

PMID41999375
PMCPMC13491069

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.