ArticleJACC. Asia2026
OCT-Guided PCI According to Lesion Length and Vessel Diameter: Post Hoc Analysis of OCCUPI Trial.
Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03625908 (Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons: a Randomized Controlled Trial (OCCUPI Trial)
Who cites it
2 citing papers in PubMed.
- Are Stent Optimization Thresholds Universal?: Insights From Small Vessels and Long Lesions.JACC. Asia · 2026Article
- Article
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Authors and funding
33 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical impact of optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) based on lesion characteristics remains unclear.
objectivesThis study aimed to assess the impact of OCT-guided PCI for complex lesions on clinical outcomes according to lesion length and reference vessel diameter (RVD).
methodsIn the OCCUPI (Optical Coherence Tomography-guided Coronary Intervention in Patients with Complex Lesions) trial, 1,604 patients with complex lesions were classified according to the median lesion length (32 mm) and RVD (2.8 mm) measured by quantitative coronary angiography. The primary endpoint was the 1-year incidence of major adverse cardiac events, a composite of cardiac death, myocardial infarction, stent thrombosis, or ischemia-driven target vessel revascularization. The median follow-up duration was 365 days (Q1-Q3: 365-365 days).
resultsThe OCT guidance group showed a lower incidence of major adverse cardiac events than the angiography guidance group in patients with lesion length ≥32 mm (HR: 0.55; 95% CI: 0.32-0.95; P = 0.031) and RVD <2.8 mm (HR: 0.51; 95% CI: 0.28-0.92; P = 0.026). Across stratified groups based on lesion length and RVD, OCT guidance consistently demonstrated a direction of effect favoring OCT-guided PCI across all lesions (P for interaction = 0.526), with a particularly significant reduction in lesions ≥32 mm with RVD <2.8 mm (HR: 0.46; 95% CI: 0.23-0.94; P = 0.041).
conclusionsThis post hoc analysis of the OCCUPI trial showed that clinical outcomes consistently favored OCT-guided PCI across varying lesion lengths and RVD, with the most pronounced benefit evident in lesions ≥32 mm with RVD <2.8 mm. (Optical CoherenCe Tomography-gUided Coronary Intervention in Patients With Complex lesIons: a Randomized Controlled Trial [OCCUPI Trial]; NCT03625908).
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