Evidence map›Paper›PMID 41999242›Full record

ArticleThe breast journal2026

A Cohort Study on Cardiovascular Disease Mortality in Breast Cancer Patients With Different Subtypes.

Zhipeng Wang, Lihong Deng, Peng Wang, Yacong Zhang, Zhongyang Shen

Abstract read
In one paragraph

Article in The breast journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhipeng WangInstitute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, China, nankai.edu.cn.ORCID 0000-0002-5686-927X
Lihong DengInstitute of Preventive Medicine, Tianjin Centers for Disease Control and Prevention, Tianjin, China.ORCID 0000-0002-0569-6188
Peng WangDepartment of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China, tijmu.edu.cn.ORCID 0000-0003-4803-2549
Yacong ZhangDepartment of Epidemiology & Biostatistics, School of Public Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Tianjin Medical University, Ministry of Education, Tianjin, China, meb.gov.tr.ORCID 0000-0002-3592-9480
Zhongyang ShenInstitute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, China, nankai.edu.cn.ORCID 0009-0000-2212-4539

Funding

National Major Scientific Research Instrument Development Project of Chin 82127808National Natural Science Foundation of China 81921004National Natural Science Foundation of China 82241219
6 · The paper itself

Abstract

purposeTo investigate cardiovascular disease (CVD) mortality among patients with different breast cancer (BC) subtypes to assess its implications for long-term survival. PATIENTS AND

methodsIn total, 423,758 BC patients were included in this study utilizing data from the Surveillance, Epidemiology, and End Results 17 Registries Database (2010-2020). Competing risk curves were utilized to assess whether the cumulative CVD mortality surpassed the cumulative BC mortality. Multivariate competing risk models were used to explore potential factors associated with CVD mortality. Standardized mortality ratios (SMRs) were calculated to investigate CVD mortality in comparison to the general population.

resultsIn total, 5863 BC patients died from CVD during follow-up time, accounting for 10.0% of all deaths (56,856). The number of deaths and the percentage of all deaths among patients died from CVD for luminal A, luminal B, HER-2 enriched, and triple-negative subtype were 4160 (12.2%), 615 (9.7%), 291 (7.7%), and 797 (6.2%), respectively. After 9 years, BC mortality remained over 10% higher than CVD mortality for luminal A and B subtypes, but the difference was under 10% for HER-2-enriched and triple-negative subtypes. HER-2-enriched and triple-negative BC patients aged 55-84 had higher CVD mortality compared to the general population. Triple-negative BC was independently associated with increased CVD mortality compared with luminal A (HR 1.103 [95% CI: 1.016-1.199]).

conclusionsPatients with the triple-negative subtype have a high risk of CVD mortality. This underscores the need for enhanced surveillance and targeted cardiovascular interventions for these patients to improve their long-term health outcomes.

Indexed as

Breast NeoplasmsCardiovascular DiseasesAdultAgedCohort StudiesFemaleHumansMiddle AgedRisk FactorsSEER Programbreast cancercardio-oncologycardiovascular mortalitymolecular subtype

Identifiers

PMID41999242
PMCPMC13091089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.