Phosphorescent Iridium Hydrazinonicotinic Acid (HYNIC) Complexes That Bind to Prostate Specific Membrane Antigen: Potential Photodynamic Therapy of Prostate Cancer.

La'El Kimchi, Emily R McGowan, Katherine A Morgan, Jonathan M White, Trevor A Smith, Stacey E Rudd, Paul S Donnelly

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

La'El KimchiSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.

Emily R McGowanSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.

Katherine A MorganSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.

Jonathan M WhiteSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.

Trevor A SmithSchool of Chemistry, University of Melbourne, Melbourne, Victoria, Australia.

Stacey E RuddSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.

Paul S DonnellySchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-5373-0080

Funding

Australian Cancer Research FoundationAustralian Research Council IC230100046National Health and Medical Research Council

6 · The paper itself

Abstract

Phosphorescent metal complexes have the potential to be used for photodynamic detection of tumor margins in surgery and photodynamic therapy (PDT). In this work, iridium(III) complexes are prepared with two cyclometalating ligands, either phenylpyridine (ppy) or phenylisoquinoline (piq), and one 6-hydrazinonicotinic acid (HYNIC) ancillary ligand to give [Ir(ppy)

Indexed as

Coordination ComplexesIridiumNicotinic AcidsPhotosensitizing AgentsProstate-Specific AntigenProstatic NeoplasmsHumansLigandsMalePhotochemotherapyCoordination ComplexesIridiumLigandsNicotinic AcidsPhotosensitizing AgentsProstate-Specific Antigenbioinorganic chemistryiridiummolecular targetingphosphorescentphotodynamic therapy

Identifiers

PMID41999076

DOI10.1002/chem.71011

PMCPMC13331583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.