Evidence map›Paper›PMID 41998858›Full record

ReviewComprehensive Physiology2026

Heart-Lung Interactions in Gas Exchange: From Physiology to Pathophysiology.

Giuseppe Miserocchi, Egidio Beretta

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Giuseppe MiserocchiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Egidio BerettaSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review outlines the physiological organization of heart-lung coupling that ensures efficient gas exchange. Subsequently, factors that compromise this efficiency are examined. The development of perturbation in lung fluid balance, originating from both capillary and alveolar sources, is discussed in detail, as it represents a frequently overlooked contributor to impaired gas exchange. Intrinsic mechanisms by which the lung resists edema formation are then presented. We provide a quantitative functional model based on physical principles to describe the diffusion-perfusion interaction in the air-blood barrier aiming to interpret several pathological conditions, including pulmonary fibrosis, lung resection, heart failure syndromes, and mechanically ventilated patients with acute hypoxemic respiratory failure (AHRF).

Indexed as

AHRFcapillary transit timelung edemalung fibrosismechanical ventilationperfusion limitationsurfactant

Identifiers

PMID41998858
PMCPMC13090562

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.