ReviewActa physiologica (Oxford, England)2026
Re-Evaluating Hot Mitochondria: Too Slow to Cool.
Review in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decoding the Hot-Mitochondrion Paradox.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
aimMito Thermo Yellow (MTY) is a mitochondrially targeted fluorophore that shows marked fluorescence quenching with increasing temperature, allowing for interrogating temperature dynamics in the mitochondria of live cells. Here we re-evaluate published MTY fluorescence responses used to argue in favor of the 'hot mitochondria' concept; the assertion that mitochondria operate while maintaining substantial (> 10°C) apparent temperature gradients (ΔT
resultsWe find that MTY fluorescence kinetics are incompatible with the expected dynamics of mitochondrial heat production and diffusion. We further explore the published effects of mitochondrial inhibitors on MTY, and related evidence for ΔT
conclusionTaken as a whole, we conclude MTY and similar tools must be re-evaluated in regard to if they are providing solely information on local temperature and thus are so far inadequate, unto themselves, to demonstrate the existence of hot mitochondria.
Indexed as
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What OpenQuestion holds
Registered trials
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