Evidence map›Paper›PMID 41998818›Full record

ArticleActa physiologica (Oxford, England)2026

Age-Related Adaptations in Renal Tubular Function in Female Rats.

Aurélie Edwards, Timothy M Reilly, Donna L Ralph, Mohammad Tajdini, Ariel M Finch, Anil Patel, Brandon E McFarlin, Hermann Koepsell, Alicia A McDonough

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aurélie EdwardsDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-3324-2108
Timothy M ReillyDepartment of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, California, USA.
Donna L RalphDepartment of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, California, USA.
Mohammad TajdiniDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
Ariel M FinchDepartment of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, California, USA.
Anil PatelDepartment of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, California, USA.
Brandon E McFarlinDepartment of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, California, USA.
Hermann KoepsellInstitute for Anatomy and Cell Biology, University of Würzburg, Würzburg, Bavaria, Germany.
Alicia A McDonoughDepartment of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, California, USA.

Funding

Sodium transporter regulation during hypertensionR01DK083785 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AURELIE EDWARDS, Alicia A. McDonough · 2011 to 2026
$5.8M
NIDDK NIH HHS R01 DK083785NIH HHS R01DK083785
6 · The paper itself

Abstract

aimPre-translational studies of mechanisms underlying chronic diseases in adult humans should ideally use animal models corresponding to mature adult rather than young animals. In this study, we examined the impact of age and past pregnancy on renal function in Sprague Dawley female rats.

methodsIn 4.5 month virgins and 12 month breeders, rates of glomerular filtration, urinary excretion, responses to diuretic and electrolyte challenges, and relative abundance of renal tubule transporters (per mg protein) were compared and simulations performed to determine the impact of age on tubular transport and energetics.

resultsTwelve month versus 4.5 month females exhibited ~25% higher GFR, lower abundance of key Na

conclusionOur findings suggest a greater propensity for sodium retention in females with age, which warrants consideration for hypertension and kidney disease studies.

Indexed as

Adaptation, PhysiologicalAgingKidney TubulesAnimalsFemaleGlomerular Filtration RateRatsRats, Sprague-Dawleyage differencesmathematical modelnephronrenal transportersrenal tubule

Identifiers

PMID41998818
PMCPMC13203048

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.