Evidence map›Paper›PMID 41998728›Full record

ArticleJournal of nanobiotechnology2026

Construction and evaluation of an engineered autonomously lysing Salmonella system coupled with self-assembled nanoparticles as a vaccine platform for antigen delivery.

Xiaoping Bian, Limin Jiang, Man Xu, Yue Sun, Xinyu Liu, Tianyu Fan, Mengru Li, Longlong Cao, Qingke Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoping BianCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China.
Limin JiangCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China.
Man XuCollege of Veterinary Medicine, Southwest University, Tiansheng Road NO. 2, Chongqing, China.
Yue SunCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China.
Xinyu LiuCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China.
Tianyu FanCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China.
Mengru LiCollege of Veterinary Medicine, Southwest University, Tiansheng Road NO. 2, Chongqing, China.
Longlong CaoCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China. caolong5955@163.com.
Qingke KongCollege of Veterinary Medicine, Shandong Agricultural University, Panhe Street NO. 7, Taian, Shandong, China. kongqiki@163.com.

Funding

National Natural Science Foundation of China 32503080Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission CSTB2025NSCQ-GPX0517Postdoctoral Innovation Program of Shandong Province SDCX-ZG-202503058the 78th batch of General Funding of the China Postdoctoral Science Foundation 2025M781384
6 · The paper itself

Abstract

Live attenuated Salmonella vectors hold great promise for antigen delivery due to their ability to elicit broad mucosal and systemic immunity, but their clinical translation is hindered by safety concerns (e.g., virulence reversion, persistent colonization) and suboptimal antigen release kinetics. Here, we devised and constructed a novel, programmed lysis system in Salmonella based on regulated delayed gene expression and integrated it with self-assembled nanoparticles to create a versatile vaccine platform. This programmed lysis system involved a tse1 gene from Pseudomonas aeruginosa (P. aeruginosa) encoding a peptidoglycan-cleaving lytic effector and a controllable promoter P

Indexed as

NanoparticlesSalmonellaSalmonella typhimuriumSalmonella VaccinesAnimalsAntibodies, BacterialAntigens, BacterialBacterial ProteinsFemaleImmunoglobulin GMiceMice, Inbred BALB CNanovaccinesPseudomonas aeruginosaStreptococcus pneumoniaeAntibodies, BacterialAntigens, BacterialBacterial ProteinsImmunoglobulin GNanovaccinespneumococcal surface protein ASalmonella VaccinesAttenuated SalmonellaAutonomously lysing systemSelf-assembled nanoparticlesVaccine platform

Identifiers

PMID41998728
PMCPMC13220505

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.