Evidence map›Paper›PMID 41998585›Full record

ArticleBMC pulmonary medicine2026

Determinants of high chronic obstructive pulmonary disease assessment test scores according to airflow limitation severity: a three-year prospective study.

Hideto Iizuka, Hidehiro Irie, Shotaro Chubachi, Keisuke Nishikawa, Takaki Nishizawa, Kohei Fukuzawa, Tetsuya Arai, Takashi Shimada, Shiro Otake, Kaori Sakurai and 8 more

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Hideto Iizuka *Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Hidehiro Irie *Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. bachibachi472000@keio.jp.
Keisuke NishikawaDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Takaki NishizawaDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kohei FukuzawaDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Tetsuya AraiDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Takashi ShimadaDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Shiro OtakeDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kaori SakuraiDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiroaki IijimaDepartment of Respiratory Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan.
Naoya TanabeDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kazuya TanimuraDepartment of Respiratory Medicine, Nara Medical University, Nara, Japan.
Kaoruko ShimizuDepartment of Respiratory Medicine, Hokkaido University, Sapporo, Japan.
Susumu SatoDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hidetoshi NakamuraDepartment of Respiratory Medicine, Saitama Medical University, Saitama, Japan.
Koichiro AsanoDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe determinants of chronic obstructive pulmonary disease (COPD) assessment test (CAT) scores according to airflow limitation severity are not fully understood.

methodsWe aimed to elucidate this by analyzing data from 378 patients with COPD, categorized into two groups based on airflow limitation severity (FEV1 > 50% [GOLD-mild] and ≤ 50% [GOLD-severe]). Within each severity group, patients were further sub-stratified by CAT score (≥ 10 vs. <10).

resultsPatients with CAT scores ≥ 10 in the GOLD-mild group were older, with more severe airflow limitation and higher prevalence of gastroesophageal reflux disease (GERD), anxiety, depression, and diabetes, whereas those in the GOLD-severe group showed higher GERD and asthma prevalences. GERD and asthma contributed predominantly to respiratory-specific items. Airflow limitation and GERD were strong determinants in both severity groups. Key determinants were anxiety and depression in the GOLD-mild group and asthma in the GOLD-severe group. These associations remained consistent over 3 years.

conclusionsThese findings offer valuable insights for managing patients with pronounced subjective symptoms in COPD.

Indexed as

AsthmaGastroesophageal RefluxPulmonary Disease, Chronic ObstructiveAgedAnxietyComorbidityDepressionDiabetes MellitusFemaleForced Expiratory VolumeHumansMaleMiddle AgedPrevalenceProspective StudiesSeverity of Illness IndexAirflow limitationAnxietyAsthmaCATComorbiditiesCOPDDepressionDMGERD

Identifiers

PMID41998585
PMCPMC13217959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.