ArticleEMBO reports2026
Stn1 promotes zebrafish oocyte development via amplifying Wnt/β-catenin signaling.
Xin Zhang, Yanpeng Zhai, Caixia Wang, Yuxue He, Yuxin He, Bo Wang, Chensong Huang, Aibo Sheng, Yan Bai, Xiaozhi Rong and 1 more
Abstract read
In one paragraphArticle in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
Xin Zhang *Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.ORCID 0000-0001-6631-6145 Yanpeng Zhai *Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Caixia Wang *Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.ORCID 0000-0002-6051-7525 Yuxue HeKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.ORCID 0009-0005-1690-0665 Yuxin HeKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Bo WangKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Chensong HuangKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Aibo ShengKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Yan BaiKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Xiaozhi RongKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China. rongxiaozhi@ouc.edu.cn.ORCID 0000-0002-8252-6289 Jianfeng ZhouKey Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China. jfzhou@ouc.edu.cn.ORCID 0000-0001-5702-6664 Funding
MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 202442003MOST | National Natural Science Foundation of China (NSFC) 31601863MOST | National Natural Science Foundation of China (NSFC) 31872189MOST | National Natural Science Foundation of China (NSFC) 32170834MOST | National Natural Science Foundation of China (NSFC) 32370867MOST | National Natural Science Foundation of China (NSFC) 32400486National Key R & D Program of China 2022YFC2804400| Natural Science Foundation of Shandong Province ( ) ZR2021MC075| Natural Science Foundation of Shandong Province ( ) ZR2025MS429
6 · The paper itselfAbstract
Wnt/β-catenin signaling regulates oocyte development in vertebrates. However, the dynamics of Wnt/β-catenin signaling in oocyte progression remain unclear. Here, we analyze oocytes across different developmental stages in zebrafish and find that the activity of Wnt/β-catenin signaling sharply increases when oocytes reach a size of 10 to 45 μm (stage IA to middle stage IB) and subsequently declines rapidly. In addition, we show that expression of the CST complex subunit Stn1 is enriched in germ cells. Stn1 interacts with the transcription factor Tcf/Lef, facilitates its association with promoters of germ cell-specific genes, thereby enhancing Wnt/β-catenin signaling activity in oocytes. Genetic deletion of stn1 leads to massive loss of oocytes prior to or during their development to stage IB, resulting in a male-like phenotype associated with infertility. Temporal activation of the Wnt/β-catenin signaling pathway partially restores germ cell loss and facilitates oocyte development to stage IB. Our findings highlight the importance of Wnt/β-catenin signaling in promoting the expression of germ cell-specific genes and provide novel insights into the physiological function of Stn1 in maintaining oocyte development in zebrafish.
Indexed as
beta CateninOocytesOogenesisWnt Signaling PathwayZebrafishZebrafish ProteinsAnimalsFemaleGene Expression Regulation, DevelopmentalMalePromoter Regions, GeneticProtein BindingTCF Transcription Factorsbeta CateninTCF Transcription FactorsZebrafish Proteins
Identifiers
PMID41998405
PMCPMC13304171
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