ReviewAnnals of biomedical engineering2026
Bioreactor-Induced Compression in Scaffolds for the Enhancement of Cartilage Regeneration: A Systematic Review.
Review in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis systematic review evaluates how bioreactor-delivered mechanical compressive stimulation in engineered cartilage scaffolds influences extracellular matrix (ECM) biosynthesis and cartilage homeostasis and seeks to clarify the conditions and parameters necessary to enhance engineered cartilage formation.
methodsA systematic literature search was developed and carried out in the MEDLINE, EMBASE, Web of Science, and Scopus databases from each database's inception to December 2024. In vitro studies reporting on bioreactors' compression effects on 3D tissue-engineered cartilage scaffolds, focusing on ECM assessment and cellular components, were included. Bioreactor-induced compression effects on ECM production, cell viability, and gene expression in chondrocytes and mesenchymal stem cells. Methodological quality was evaluated using an assessment tool specific to in vitro studies, evaluating the quality of reporting, replicability, and internal and external validity.
resultsFollowing PRISMA guidelines, 30 in vitro studies were included for analysis of information. The findings reveal that mechanical stimulation, particularly cyclic compression (5-20% strain at 0.5-1 Hz), significantly improves ECM composition, with increases in glycosaminoglycans and type II collagen, while reducing hypertrophic markers.
conclusionOptimal bioreactor conditions were found to vary depending on cell type, scaffold material, and loading parameters, emphasizing the importance of tailored approaches. Additionally, biomaterials mimicking native cartilage properties enhanced the outcomes of mechanical stimulation by supporting cell differentiation and ECM deposition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.