Evidence map›Paper›PMID 41998300›Full record

ArticleLeukemia2026

Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML.

Nathan Duong, Dilshad H Khan, Geethu E Thomas, Yue Feng, Rose Hurren, Jong Bok Lee, Jonathan St-Germain, Lily Drimmer, Yongran Yan, Lan Xin Zhang and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Nathan DuongPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-7171-5554
Dilshad H KhanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Geethu E ThomasPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Yue FengPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Rose HurrenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Jong Bok LeeToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Jonathan St-GermainPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Lily DrimmerPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Yongran YanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0009-0005-7337-4331
Lan Xin ZhangPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Karen Kai-Lin FangPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Dakai LingPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Mary L MaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Neil MacLeanPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Marcela GrondaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Vincent RondeauPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Brandon D BrownMD Anderson Cancer Centre, Houston, TX, USA.
Laura MatellánLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-6897-0148
Courtney L JonesPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Hong ChangLaboratory Medicine Program, Department of Laboratory Hematology, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3106-2776
Andrea ArrudaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Stephanie XiePrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0284-494X
Laurence PelletierLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Mark D MindenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Li ZhangToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Steven M KornblauMD Anderson Cancer Centre, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5990-9548
Brian RaughtPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Kevin JacobsInterlinked Therapeutics, Portland, OR, USA.
Max G JacobsInterlinked Therapeutics, Portland, OR, USA.
Daniel GoedeInterlinked Therapeutics, Portland, OR, USA.
Vito SpadavecchioInterlinked Therapeutics, Portland, OR, USA.
Aaron D SchimmerPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Aaron.schimmer@uhn.ca.ORCID http://orcid.org/0000-0003-4023-3899

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) CIHR FDN 154282
6 · The paper itself

Abstract

Interleukin-23 receptor (IL-23R) is a cell surface cytokine receptor classically expressed on T cells, where it regulates T cell activation. Here, we discovered a novel intracellular localization and function for IL-23R in Acute Myeloid Leukemia (AML). Compared to normal hematopoietic cells, IL-23R was increased in primary AML samples. IL-23R was predominantly localized intracellularly in AML cells. BioID mass spectrometry identified mitotic spindle proteins as top interactors with IL-23R. We confirmed interaction between endogenous IL-23R and the mitotic spindle in AML cells and primary AML samples, and this interaction was mediated by IL-23R's (S/T)x(I/L)P motif. Genetic depletion of IL-23R disrupted mitotic spindle formation and reduced proliferation and stem cell/progenitor function of AML cell lines and primary AML samples. In contrast, depletion of IL-23R spared normal hematopoietic cells and progenitors. Thus, we discovered a novel intracellular function for IL-23R where this receptor regulates mitotic spindle formation and the growth of AML cells.

Indexed as

Leukemia, Myeloid, AcuteReceptors, InterleukinSpindle ApparatusCell ProliferationCell SurvivalHumansIL23R protein, humanReceptors, Interleukin

Identifiers

PMID41998300
PMCPMC13149024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.