Evidence map›Paper›PMID 41998282›Full record

ArticleNature ecology & evolution2026

Dynamics and ecology of a multistage expansion of Oropouche virus in Brazil.

Houriiyah Tegally, Simon Dellicour, Jenicca Poongavanan, Carla Mavian, Graeme Dor, Vagner Fonseca, Massimiliano S Tagliamonte, Marcel Dunaiski, Monika Moir, Eduan Wilkinson and 11 more

Abstract read
In one paragraph

Article in Nature ecology & evolution, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Viruses · 2025
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Houriiyah Tegally *Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa. houriiyah@sun.ac.za.ORCID http://orcid.org/0000-0002-7102-8540
Simon Dellicour *Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium.ORCID http://orcid.org/0000-0001-9558-1052
Jenicca Poongavanan *Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
Carla Mavian *Emerging Pathogens Institute, Department of Pathology, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-3819-5520
Graeme DorCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0001-9036-9933
Vagner FonsecaCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0001-5521-6448
Massimiliano S TagliamonteInterdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA.
Marcel DunaiskiComputer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0003-1957-3979
Monika MoirCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
Eduan WilkinsonCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
Carlos Frederico Campelo de AlbuquerqueOrganização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Brazil.ORCID http://orcid.org/0000-0003-0581-5535
Livia C V FrutuosoCoordenadora-Geral de Vigilância de Arboviroses, Brazilian Ministry of Health, Brasília, Brazil.
Edward C HolmesSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9596-3552
Cheryl BaxterCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.
Richard LessellsKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.ORCID http://orcid.org/0000-0003-0926-710X
Moritz U G KraemerPandemic Sciences Institute, University of Oxford, Oxford, UK.
José LourençoUniversidade Católica Portuguesa, Católica Medical School, Católica Biomedical Research Center, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-9318-2581
Luiz Carlos Junior AlcantaraInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Tulio de OliveiraCentre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa. tulio@sun.ac.za.ORCID http://orcid.org/0000-0002-3027-5254
Marta GiovanettiOswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. giovanetti.marta@gmail.com.ORCID http://orcid.org/0000-0002-5849-7326
Consortium CLIMADE

Funding

Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) 101103171EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101094685EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 874850Fonds De La Recherche Scientifique - FNRS (Belgian National Fund for Scientific Research) F.4515.22Novo Nordisk NNF24OC0094346Rockefeller Foundation HTH 017Wellcome Trust (Wellcome) 228186/Z/23/ZWorld Bank Group (World Bank) TF0B8412
6 · The paper itself

Abstract

In March 2024, Brazil reported an unprecedented Oropouche fever outbreak, driven by the emergence of a reassortant lineage of the Oropouche virus (OROV) expanding beyond the Amazon Basin. To investigate the expansion dynamics of OROV, we implemented complementary phylogeographic and ecological niche modelling approaches that aimed to characterize the environmental factors associated with the range expansion and the risk of local circulation, respectively. Our analyses reveal a multiscale expansion process with both short- and long-distance dispersal events and diffusion velocities in line with air traffic-mediated jumps. We identify banana and cocoa cultivation, temperature, the predicted suitability of the primary vector Culicoides paraensis and human population density as key environmental factors associated with OROV range expansion in new areas. We further show that OROV circulated in areas of enhanced ecological suitability immediately preceding its explosive epidemic expansion in the Amazon. Our study provides valuable insights into the dispersal and ecological dynamics of OROV, highlighting the probable role of human mobility in the long-distance colonization of new areas and raising concern over high viral suitability along the Brazilian coast.

Indexed as

Bunyaviridae InfectionsOrthobunyavirusAnimalsBrazilCeratopogonidaeEcosystemPhylogeography

Identifiers

PMID41998282
PMCPMC13253323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.