Evidence map›Paper›PMID 41998271›Full record

ArticleScientific reports2026

Evaluation of the antifungal efficacy of microbial chondroitin sulfate against candida species in an experimental rat model of vulvovaginal candidiasis.

Rauf Melekoglu, Ayse Sebnem Erenler, Mustafa Huz, Tuba Unver, Feyza Inceoglu, Suleyman Koytepe, Hikmet Geckil, Nusret Akpolat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rauf MelekogluDepartment of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, 44280, Turkey. rauf.melekoglu@inonu.edu.tr.ORCID http://orcid.org/0000-0001-7113-6691
Ayse Sebnem ErenlerDepartment of Medical Biology, Faculty of Medicine, Malatya Turgut Ozal University, Malatya, 44210, Turkey.ORCID http://orcid.org/0000-0002-1786-5022
Mustafa HuzDepartment of Pathology, Faculty of Medicine, Inonu University, Malatya, 44280, Turkey.ORCID http://orcid.org/0000-0003-4474-256X
Tuba UnverDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Inonu University, Malatya, 44280, Turkey.ORCID http://orcid.org/0000-0002-8655-2716
Feyza InceogluDepartment of Biostatistics, Faculty of Medicine, Malatya Turgut Ozal University, Malatya, 44210, Turkey.ORCID http://orcid.org/0000-0003-1453-0937
Suleyman KoytepeDepartment of Chemistry, Science Faculty, Inonu University, Malatya, 44280, Turkey.ORCID http://orcid.org/0000-0002-4788-278X
Hikmet GeckilDepartment of Molecular Biology and Genetics, Science Faculty, Inonu University, Malatya, 44280, Turkey.ORCID http://orcid.org/0000-0003-0070-0691
Nusret AkpolatDepartment of Pathology, Faculty of Medicine, Inonu University, Malatya, 44280, Turkey.ORCID http://orcid.org/0000-0002-9138-2117

Funding

Research Fund of Inonu University Project no. FDK-2022-3108
6 · The paper itself

Abstract

Chondroitin sulfate (CS) is a glycosaminoglycan with various biological functions including antioxidant and anti-inflammatory effects. Candida species, particularly Candida albicans, are major pathogens involved in vulvovaginal candidiasis (VVC), which affects a majority of women, and novel antifungal agents are needed due to the limitations of current treatments. This study evaluated the antifungal efficacy of microbial chondroitin sulfate (MCS), produced via recombinant Escherichia coli (C2987), in a rat model of VVC. MCS was biosynthesized via the pETM6-PACF-vgb

Indexed as

Antifungal AgentsCandidaCandidiasis, VulvovaginalChondroitin SulfatesAnimalsCandida albicansCytokinesDisease Models, AnimalEscherichia coliFemaleRatsRats, WistarAntifungal AgentsChondroitin SulfatesCytokinesAntifungal activityCandida spp.Microbial chondroitin sulfateVaginal candidiasis

Identifiers

PMID41998271
PMCPMC13247106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.