ArticleAntonie van Leeuwenhoek2026
Diversity and antimicrobial products of culturable coral-associated actinomycetes in Hainan.
Article in Antonie van Leeuwenhoek, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Actinomycetes are a group of microorganisms with significant biological and applied value, widely distributed in natural environments, particularly in ecosystems such as soil, plant rhizosphere, and aquatic sediments. Due to their complex genomes and metabolic pathways, actinomycetes play a crucial role in drug development. Seventy-seven coral-associated actinomycetes were obtained from five different corals collected from the coast of Wenchang, Hainan (China) and 16S rRNA gene sequence analysis revealed that they belonged to eight genera. Among them, Streptomyces and Micromonospora were the dominant genera, accounting for 32.47% and 29.87% of the total isolates, respectively. Antimicrobial screening revealed that approximately 10% of the actinomycete isolates exhibited antibacterial activity. Salinispora sp. HNM0925 and Streptomyces sp. HNM0560 exhibited antagonistic effects against various pathogens (Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae, Bacillus subtilis, MRSA). The active compounds responsible for the antibacterial activity of strains HNM0925 and HNM0560 in their fermentation broths were identified as rifamycin S and actinomycin D, respectively. Both compounds exhibited minimum inhibitory concentrations (MICs) lower than those of commonly used antibiotics, including ampicillin, norfloxacin, tobramycin, and linezolid, indicating superior antibacterial efficacy compared with these standard antibiotics. The results of this study demonstrate the diversity and antibacterial potential of culturable coral-associated actinomycetes from the coastal region of Wenchang, highlighting their value as a source of candidate strains for antimicrobial drug discovery.
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