Evidence map›Paper›PMID 41998161›Full record

ArticleNature microbiology2026

Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice.

Siqi Ji, Yuanhui Liu, Yuejie Xu, Junzhao Gao, Jingzheng Jin, Ping Jiang, Yixuan Li, Dan Su, Yu Zhao, Shuqiao Yang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Siqi Ji *Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yuanhui Liu *Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yuejie Xu *Department of Gastroenterology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Jiangsu Branch of the National Clinical Research Center for Digestive Diseases, Wuxi, Jiangsu, China.
Junzhao Gao *Department of Nutrition and Health, China Agricultural University, Beijing, China.
Jingzheng JinDivision of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ping JiangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing, Jiangsu, China.
Yixuan LiDepartment of Nutrition and Health, China Agricultural University, Beijing, China.
Dan SuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Yu ZhaoUniversity of Chicago, Pritzker School of Molecular Engineering, Chicago, IL, USA.
Shuqiao YangHubei Hongshan Laboratory, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, Hubei, China.
Shuai ZhangHubei Hongshan Laboratory, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, Hubei, China. shuaizhang@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0001-5044-9947
Wenbiao ShiDepartment of Nutrition and Health, China Agricultural University, Beijing, China. wenbiao.shi@cau.edu.cn.ORCID http://orcid.org/0000-0001-7724-9582
Qian ZhouCancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. zqsmile.0214@foxmail.com.ORCID http://orcid.org/0000-0003-1471-6651
Mingming ZhangDivision of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; State Key Laboratory for Oncogenes and Related Genes; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. doczmm@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-6907-4049

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82322010
6 · The paper itself

Abstract

Microbiome-host interactions can influence colorectal cancer (CRC) outcomes and the effectiveness of immunotherapy treatment, but the precise mechanisms underlying this are poorly understood. Here we analyse CRC patient cohort data and observe that Facalibacterium prausnitzii abundance in faecal samples correlates with improved CRC survival outcome and immunotherapy response. In vitro assays and experiments in azoxymethane plus dextran sulfate sodium (AOM/DSS) and Apc

Indexed as

B7-H1 AntigenColorectal NeoplasmsFaecalibacterium prausnitziiImmunotherapyRibose-Phosphate PyrophosphokinaseAnimalsCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalFecesFemaleHumansMiceMice, Inbred C57BLrab GTP-Binding ProteinsB7-H1 AntigenCD274 protein, humanrab GTP-Binding ProteinsRibose-Phosphate Pyrophosphokinase

Identifiers

PMID41998161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.