ArticleScientific reports2026
Tertiary alcohol-containing polycyclic polyprenylated acylphloroglucinols from Hypericum scabrum inhibit the proliferation of oral squamous cell carcinoma CAL-27 cells.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polycyclic polyprenylated acylphloroglucinols (PPAPs) represent a structurally diverse class of natural products with reported biological activities, yet their effects on oral squamous cell carcinoma (OSCC) remain insufficiently characterized. In this study, fourteen tertiary alcohol-containing PPAPs, including seven previously undescribed compounds, were isolated from Hypericum scabrum Linn and structurally elucidated by spectroscopic methods. Their antiproliferative activities were evaluated in CAL-27 human OSCC cells. PPAPs were isolated and purified by means of column chromatography combined with semi-preparative techniques, then chemical structures were characterized using nuclear magnetic resonance (NMR) spectroscopy. The half-maximal inhibitory concentration (IC₅₀) values of these phloroglucinol compounds against CAL-27 cells were determined via the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyl tetrazolium bromide (MTT) assay. Furthermore, the in vitro mechanism underlying the action of these compounds on CAL-27 cells was elucidated through an integrated approach involving RNA sequencing (RNA-Seq), quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analysis. Fourteen tertiary alcohol-containing PPAPs were isolated and structurally characterized, including seven new analogs (1-7). Among these, compound 13 was found to be the potential cytotoxic active compound against CAL-27 during in-vitro tests, with IC
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