Lactobacillus paragasseri ameliorates age-dependent thermotaxis decline in Caenorhabditis elegans.

Masaru Tanaka, Sachio Tsukada, Moon Sun Jang, Binta Maria Aleogho, Ikue Mori, Kentaro Noma

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Masaru TanakaMilk Science Research Institute, MEGMILK SNOW BRAND Co. Ltd.,, 1-1-2 Minamidai, 350-1165, Kawagoe, Saitama, Japan.

Sachio TsukadaMilk Science Research Institute, MEGMILK SNOW BRAND Co. Ltd.,, 1-1-2 Minamidai, 350-1165, Kawagoe, Saitama, Japan.

Moon Sun JangGroup of Molecular Neurobiology, Neuroscience Institute, Graduate School of Science, Nagoya University, 464-8602, Nagoya, Japan.

Binta Maria AleoghoGroup of Nutritional Neuroscience, Neuroscience Institute, Graduate School of Science, Nagoya University, Nagoya, 464-8602, Japan.

Ikue MoriGroup of Molecular Neurobiology, Neuroscience Institute, Graduate School of Science, Nagoya University, 464-8602, Nagoya, Japan.

Kentaro NomaGroup of Nutritional Neuroscience, Neuroscience Institute, Graduate School of Science, Nagoya University, Nagoya, 464-8602, Japan. noma.kentaro.f1@f.mail.nagoya-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet can modulate cognitive aging, but the underlying mechanisms are poorly understood. Here, we show that specific lactic acid bacteria (LAB) ameliorate age-dependent decline of associative learning behavior in the nematode Caenorhabditis elegans. Screening of LAB and bifidobacterial species, mixed with the standard Escherichia coli (E. coli) diet, revealed that Lactobacillus paragasseri (Lb. paragasseri) protects against behavioral aging without affecting growth, lipid storage, or lifespan. Different treatment of bacteria suggested that Lb. paragasseri contains heat-labile, yet freeze-stable bacterial components responsible for the beneficial effect. Calcium imaging revealed that Lb. paragasseri suppresses age-associated hyperactivation of AWC sensory neurons, a key driver of behavioral decline. Furthermore, the influence of Lb. paragasseri required the FOXO transcription factor DAF-16. Proteomic profiling identified differentially expressed proteins between aged animals fed E. coli alone and those fed a mixture of E. coli and Lb. paragasseri. Together, these findings highlight Lb. paragasseri as a potential microbiota-based intervention for preserving neural function during aging.

Indexed as

AgingCaenorhabditis elegansLactobacillusTaxis ResponseAnimalsCaenorhabditis elegans ProteinsEscherichia coliForkhead Transcription FactorsLongevityProteomicsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansForkhead Transcription Factors

Identifiers

PMID41998110

DOI10.1038/s41598-026-48002-7

PMCPMC13249960

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.