Evidence map›Paper›PMID 41998081›Full record

ReviewCommunications biology2026

Neurexins, Ephrin receptors, and N-cadherin signaling as emerging mechanisms in synaptic dysfunction and neurodegenerative diseases.

João Gonçalves-Martins, Carlos Cação, Joana S Ferreira

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

João Gonçalves-Martins *Multidisciplinary Institute of Ageing, MIA-Portugal, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0003-1487-4211
Carlos Cação *Multidisciplinary Institute of Ageing, MIA-Portugal, University of Coimbra, Coimbra, Portugal.ORCID http://orcid.org/0000-0003-2625-8731
Joana S FerreiraMultidisciplinary Institute of Ageing, MIA-Portugal, University of Coimbra, Coimbra, Portugal. joana.s.ferreira@uc.pt.ORCID http://orcid.org/0000-0002-1049-8063

Funding

Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) Young Investigator Grant 2021
6 · The paper itself

Abstract

Synaptic cell adhesion molecules (SAMs) are essential for axon pathfinding and synaptic establishment during neurodevelopment, bridging the pre- and postsynaptic compartments across the synaptic cleft. While this function is well established, recent evidence has shown these proteins also exert key neuronal functions throughout the neuron's life, regulating neuronal communication at mature synapses. Given these novel roles, SAMs are emerging as important elements relating to mental health and as significant contributors to age-related diseases, such as neurodegenerative disorders. For insight into this emerging role of SAMs, we focused on three pivotal regulator families of the central nervous system: Neurexins, Ephrin Receptors, and N-cadherins.

Indexed as

CadherinsEphrinsNeurexinsNeurodegenerative DiseasesReceptors, Eph FamilySignal TransductionSynapsesAnimalsHumansNeurodevelopmentCadherinsEphrinsNeurexinsReceptors, Eph Family

Identifiers

PMID41998081
PMCPMC13149691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.